Cetrimonium Bromide (CTAB)

製品コードS4242 バッチS424201

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₉H₄₂N.Br
	分子量	364.45	CAS No.	57-09-0
Solubility (25°C)*	体外	Water	100 mg/mL (274.38 mM)
		Ethanol	100 mg/mL (274.38 mM)
		DMSO	5 mg/mL (13.71 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cetrimonium Bromide (CTAB) is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.
in vitro	Cetrimonium Bromide reduces cell viability of FaDu, C666-1, UTSCC-8A, UTSCC-42A, MRC5 cells and GM05757 fibroblasts with EC50 of 2 μM, 3.8 μM, 3.5 μM, 4.2 μM, 11 μM and 18 μM, respectively. Cetrimonium Bromide reduces cell viability of A549 lung and MCF7 breast cancer cells with EC50 of 17 μM and 12 μM. Cetrimonium Bromide (0.5 μM) interacts additively with radiation in a dose-dependent manner to exhibits inhibition effect on the clonogenic survival of FaDu cells. Cetrimonium Bromide results in nuclear condensation and blebbing in FaDu cells, consistent with apoptotic nuclear morphology, which is not observed in CTAB-treated GM05757 fibroblasts. Cetrimonium Bromide reproducibly decreases ATPase activity in a dose-dependent manner in FaDu cells, achieving ∼90% inhibition at 50 μM. Cetrimonium Bromide (5 μM) causes a modest (∼10%), but statistically significant decreases in ATP content in FaDu cells. Cetrimonium Bromide (5 μM) induced apoptosis is significantly suppressed by >50% when CCCP (5 μM) is used to effectively uncouple ΔΨM before Cetrimonium Bromide treatment in FaDu cells. ^[1]
in vivo	Cetrimonium Bromide (5 μM) effectively eliminates the tumor-forming potential of FaDu cells in SCID mice. Cetrimonium Bromide (daily 5 mg/kg i.p. for 5 days) induces a modest reduction in tumor development compared with the vehicle-treatment arm in established FaDu xenograft tumors in SCID mice. ^[1]

プロトコル(参考用のみ)

参考

[1] Ito E, et al. Mol Pharmacol, 2009, 76(5), 969-983.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Cetrimonium bromide promotes lipid clearance via TFEB-mediated autophagy-lysosome activation in hepatic cells [ Biochem Cell Biol, 2021, 10.1139/bcb-2020-0570]	PubMed: 33560918
Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator [Li Z, et al. Micromachines (Basel), 2018, 9(6)]	PubMed: 30424207

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。