Cetuximab (anti-EGFR)

製品コード：A2000         Batch: A200009

印刷

Cetuximab, a novel molecular-targeted agent,is an inhibitor of EGFR monoclonal humanized antibody interacting with the extracellular binding site of EGFR to block ligand stimulation. MW : 145.781 KD.

製品説明

CAS No. 205923-56-4
Formulation 100 mM Pro-Ac, 20 mM Arg, pH5.0
Isotype Human IgG1
Source CHO cells
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping Shipped under low temperature conditions
Purity 99%
Protein concentration 7.55mg/ml
Endotoxin Level ＜1EU/mg

カスタマーフィードバック

Cetuximab-A200001X0120190320.gif

数据来源于[Data independently produced by , , J Thorac Oncol, 2018, 13(6):810-820]

Mice showed progression disease to first-line treatment were randomized 1:1 to the two arms of treatment and were treated until onset of progression disease or until the end-time of experiment in case of response (fixed to 52 weeks from the start of first-line therapy ), as indicated in in the Materials and Methods section. Growth curves of HCC827 xenografts treated in secondline with osimertinib plus selumetinib or cetuximab are represented as changes in the values of volumes as percentage compared to baseline tumor volume at the time of progression diasease to first-line (defined as 100%) for each case. Median tumor volume at PD2 was of 348 mm3.

Cetuximab-A200001Z0120180205.gif

数据来源于[Data independently produced by , , ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Artesunate Nanoplatform Targets the Serine-MAPK Axis in Cancer-Associated Fibroblasts to Reverse Photothermal Resistance in Triple-Negative Breast Cancer [ Adv Mater, 2025, e2502617] PubMed: 40528526
Oncogenic RARγ isoforms promote head and neck cancer proliferation through vinexin-β-mediated cell cycle acceleration and autocrine activation of EGFR signal [ Int J Biol Sci, 2025, 21(1):1-16] PubMed: 39744424
A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer [ Cell Commun Signal, 2025, 23(1):328] PubMed: 40635045
LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway [ Front Immunol, 2025, 16:1549749] PubMed: 40292295
Potassium Iodide Induces Apoptosis in Salivary Gland Cancer Cells [ Int J Mol Sci, 2025, 26(11)5199] PubMed: 40508009
Sprinkling in extra validation for high-value PTMs and therapeutic Abs with MILKSHAKE Western blots and Sundae ELISAs [ N Biotechnol, 2025, 89:11-19] PubMed: 40482963
Bioluminescence-based assays for quantifying endogenous protein interactions in live cells [ J Biol Chem, 2025, 301(8):110454] PubMed: 40617353
The RASAL2 variant promotes aberrant RAS signaling and resistance to anti-EGFR therapy in colorectal cancer [ Sci Rep, 2025, 15(1):31076] PubMed: 40849341
Base editing screens define the genetic landscape of cancer drug resistance mechanisms [ Nat Genet, 2024, 10.1038/s41588-024-01948-8] PubMed: 39424923
The effector program of human CD8 T cells supports tissue remodeling [ J Exp Med, 2024, 221(2)e20230488] PubMed: 38226976

人間や獣医の診断であるか治療的な使用のためにでない。