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Synonyms | CPZ | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C17H19ClN2S |
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分子量 | 318.86 | CAS No. | 50-53-3 | |
Solubility (25°C)* | 体外 | DMSO | 64 mg/mL (200.71 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM. |
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in vitro | Chlorpromazine exerts a mild decrease in sEV uptake in only one MM cell line, indicating that the uptake of BMSC-derived sEVs by suspension MM cells may not rely on chlorpromazine-targeted receptors.[1] |
in vivo | Chlorpromazine suppresses the growth of endometrial cancer (EC) tumors in vivo at a low dose with no signs of toxicity.[2] |
細胞アッセイ | 細胞株 | MM1S cells, RPMI 8226, U266, H929 cells |
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濃度 | 5, 10, 20 μM | |
反応時間 | 30 min for MM1S cells, 4.5 h for RPMI 8226, U266, H929 cells | |
実験の流れ | MM1S cells pre-treated with heparin, cytochalasin D (Cyto D), dynasore, genistein, or chlorpromazine (CPZ) at the indicated concentrations for 30 min are cultured with 50 μg/mL DID-labeled BMSC-derived sEVs for another 4 h. The mean fluorescence intensity of DID in these cells is determined using flow cytometry. RPMI 8226, U266, or H929 cells are treated with heparin, Cyto D, dynasore, genistein, or CPZ at the indicated concentration for 4.5 h in the absence of sEVs and their cell viability is measured. |
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動物実験 | 動物モデル | female BALB/c nude mice |
投薬量 | 3 or 12 mg/kg | |
投与方法 | i.p. |
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Gonococcal OMV-delivered PorB induces epithelial cell mitophagy [ Nat Commun, 2024, 15(1):1669] | PubMed: 38396029 |
Real-Time Dissection of the Transportation and miRNA-Release Dynamics of Small Extracellular Vesicles [ Adv Sci (Weinh), 2023, 10(7):e2205566] | PubMed: 36599707 |
Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA [ Int J Nanomedicine, 2023, 18:4647-4662] | PubMed: 37605735 |
Porcine deltacoronavirus enters ST cells by clathrin-mediated endocytosis and does not require Rab5, Rab7, or Rab11 [ Microbiol Spectr, 2023, 10.1128/spectrum.02553-23] | PubMed: 37962380 |
Evaluation of the liver targeting and anti‑liver cancer activity of artesunate‑loaded and glycyrrhetinic acid‑coated nanoparticles [ Exp Ther Med, 2023, 26(5):516] | PubMed: 37854499 |
Polyaniline-Based Glyco-Condensation on Au Nanoparticles Enhances Immunotherapy in Lung Cancer [ ACS Appl Mater Interfaces, 2022, 14(21):24144-24159] | PubMed: 35579575 |
Hsp90 Regulates GCRV-II Proliferation by Interacting with VP35 as Its Receptor and Chaperone [ J Virol, 2022, 96(19):e0117522] | PubMed: 36102647 |
Hsp90 Regulates GCRV-II Proliferation by Interacting with VP35 as Its Receptor and Chaperone [ Journal of Virology, 2022, Vol. 96, No. 19] | PubMed: None |
Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects [ Bioorg Chem, 2022, 127:106008] | PubMed: 35868106 |
Channel catfish virus entry into host cells via clathrin-mediated endocytosis [ Virus Res, 2022, 315:198794] | PubMed: 35504448 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。