Chlorpromazine

製品コードS5749 バッチS574902

印刷

化学情報

Chemical Structure Synonyms CPZ Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C17H19ClN2S
分子量 318.86 CAS No. 50-53-3
Solubility (25°C)* 体外 DMSO 64 mg/mL (200.71 mM)
 
 
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.
in vitro

Chlorpromazine exerts a mild decrease in sEV uptake in only one MM cell line, indicating that the uptake of BMSC-derived sEVs by suspension MM cells may not rely on this compound-targeted receptors.[1]
in vivo

Chlorpromazine suppresses the growth of endometrial cancer (EC) tumors in vivo at a low dose with no signs of toxicity.[2]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 MM1S cells, RPMI 8226, U266, H929 cells
濃度 5, 10, 20 μM
反応時間 30 min for MM1S cells, 4.5 h for RPMI 8226, U266, H929 cells
実験の流れ

MM1S cells pre-treated with heparin, cytochalasin D (Cyto D), dynasore, genistein, or chlorpromazine (CPZ) at the indicated concentrations for 30 min are cultured with 50 μg/mL DID-labeled BMSC-derived sEVs for another 4 h. The mean fluorescence intensity of DID in these cells is determined using flow cytometry. RPMI 8226, U266, or H929 cells are treated with heparin, Cyto D, dynasore, genistein, or this compound at the indicated concentration for 4.5 h in the absence of sEVs and their cell viability is measured.
動物実験 動物モデル female BALB/c nude mice
投薬量 3 or 12 mg/kg
投与方法 i.p.

参考

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797667/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087176/

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。