Cholic acid

製品コードS3742 バッチS374201

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₄H₄₀O₅
	分子量	408.57	CAS No.	81-25-4
Solubility (25°C)*	体外	DMSO	81 mg/mL (198.25 mM)
		Ethanol	28 mg/mL (68.53 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cholic acid is a naturally occurring bile acid that is insoluble in water and is used to treat patients with genetic deficiencies in the synthesis of bile acids.
in vitro	Fosfomycin is known to inhibit MurA by covalently binding to a highly conserved cysteine in the active site of the enzyme. Fosfomycin is a PEP mimetic that acts by alkylating the highly conserved Cys115 (Escherichia coli numbering) of MurA^[1]. Fosfomycin exerts immunomodulatory effects by altering lymphocyte, monocyte and neutrophil function. It affects the acute inflammatory cytokine response in vitro and in vivo. It suppresses production of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and IL-1α and increases production of IL-10. Fosfomycin suppresses IL-2 production from T cells, the production of leukotriene B4 (LTB4) from neutrophils, and the expression of IL-8 mRNA by LTB4 from monocytes. Fosfomycin also exhibits an immunomodulatory effect on B-cell activation. Fosfomycin enhances neutrophil phagocytic killing of invading pathogens, even in patients on chronic hemodialysis and renal transplantation. Fosfomycin resulted in enhanced bactericidal ability of neutrophils compared to other antimicrobials. Fosfomycin has the ability to penetrate into biofilms. fosfomycin is considerably active against both Gram-negative and Gram-positive pathogens^[2].
in vivo	The oral bioavailability of fosfomycin trometamol ranges between 34 and 58%. Absorption occurs in the small intestine, and evidence suggests that coadministration of fosfomycin trometamol with food may reduce absorption of the drug.The mean serum elimination half-life (t1/2) of fosfomycin trometamol is estimated at 5.7 h. Fosfomycin is excreted nonmetabolized in the urine, through glomerular filtration. Depending on age, fasting, and renal function, 11 to 60% of the drug can be found in the urine within 24 h from administration. Specifically, older age, administration with a meal, and deteriorating renal function result in slower elimination through the kidneys. Fosfomycin crosses the blood-brain barrier, and meningeal inflammation increases its concentration in the CSF. Fosfomycin also penetrates in both cortical and cancellous bone, and penetration correlates with plasma levels and the presence of inflammation^[2].

プロトコル(参考用のみ)

参考

[1] Bensen DC, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012, 68(Pt 4):382-5.
[2] Matthew E. Falagas, et al. Clinical Microbiology reviews. 2016, 29(2):321-347.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma [ Nat Commun, 2021, 12(1):6479]	PubMed: 34759281

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma [ Nat Commun, 2021, 12(1):6479]

PubMed: 34759281

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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