Ciclesonide

製品コードS4646 バッチS464602

印刷

化学情報

Chemical Structure Synonyms Alvesco, Omnaris, RPR251526, Zetonna Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C32H44O7
分子量 540.69 CAS No. 126544-47-6
Solubility (25°C)* 体外 DMSO 100 mg/mL (184.94 mM)
Ethanol 100 mg/mL (184.94 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.
in vitro Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Human alveolar type II epithelial cells (A549).
濃度 0.02 μM
反応時間 1 h
実験の流れ Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS.
動物実験 動物モデル Wistar rats
投薬量 0.5 mg/kg
投与方法 i.v.

参考

  • https://pubmed.ncbi.nlm.nih.gov/17122529/
  • https://pubmed.ncbi.nlm.nih.gov/17900334/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells [ bioRxiv, 2025, 2025.06.23.660251] PubMed: 40666974
Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease [ Acta Pharm Sin B, 2023, 13(2):662-677] PubMed: 36873178
The Pathophysiology of COVID-19 and SARS-CoV-2 Infection: The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a [ Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736.] PubMed: 36976925
The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid ciclesonide [ Am J Physiol Lung Cell Mol Physiol, 2023, 324(5):L722-L736] PubMed: 36976925
[Directed differentiation of human induced pluripotent stem cells into midbrain] [ Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(2):175-182] PubMed: 36946035
Co-administration of Favipiravir and the Remdesivir Metabolite GS-441524 Effectively Reduces SARS-CoV-2 Replication in the Lungs of the Syrian Hamster Model [ mBio, 2022, 13(1):e0304421] PubMed: 35100870
The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b [ Pharmaceutics, 2022, 14(7)1511] PubMed: 35890406
Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients [ J Cell Biochem, 2022, 10.1002/jcb.30213] PubMed: 35037717
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction [ Drug Test Anal, 2020, 10.1002/dta.2917] PubMed: 32852861

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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