Cinnamic acid

製品コードS3677 バッチS367701

印刷

化学情報

Chemical Structure Synonyms trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H8O2
分子量 148.16 CAS No. 140-10-3
Solubility (25°C)* 体外 DMSO 29 mg/mL (195.73 mM)
Ethanol 29 mg/mL (195.73 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Cinnamic acid（ベンゼンプロペン酸、イソケイ皮酸、トランスケイ皮酸、フェニルアクリル酸）は、毒性の低い天然の芳香族脂肪酸であり、in vitroでヒト腫瘍細胞の細胞増殖抑制と悪性特性の逆転を誘導します。
in vitro Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. This compound shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells. It upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. Expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by this chemical.
in vivo In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Thus, this compound exhibits a low toxicity. It could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses.

プロトコル(参考用のみ)

細胞アッセイ 細胞株 HT-144
濃度 0.0125 to 3.2 mM
反応時間 48 h
実験の流れ Briefly, 1 × 104 cells are seeded in each well containing 100 μL of DMEM plus 10% of FBS in a 96-well plate. After 24 h, various concentrations of this compound are added. The control group receives rug-free medium. After 2 days, 15 μL of "Dye Solution" are added to each well and the plates were incubated for additional 4 h. Then, 100 μL of “Solubilization/Stop Solution” are added in each well and the optical density is measured at 570 nm
動物実験 動物モデル BALB/c nude mice
投薬量 1.0 and 1.5 mmol/kg
投与方法 intragastrically administered

参考

  • https://pubmed.ncbi.nlm.nih.gov/23701745/
  • https://pubmed.ncbi.nlm.nih.gov/27035417/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Cinnamic acid inhibits cell viability, invasion, and glycolysis in primary endometrial stromal cells by suppressing NF-κB-induced transcription of PKM2 [ Biosci Rep, 2021, BSR20211828] PubMed: 34499120
Cinnamic acid inhibits cell viability, invasion, and glycolysis in primary endometrial stromal cells by suppressing NF-κB-induced transcription of PKM2 [ Bioscience Reports, 2021, BSR20211828] PubMed: 34499120.0

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。