Cinnamic acid

製品コードS3677 バッチS367701

印刷

化学情報

Chemical Structure Synonyms trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H8O2
分子量 148.16 CAS No. 140-10-3
Solubility (25°C)* 体外 DMSO 29 mg/mL (195.73 mM)
Ethanol 29 mg/mL (195.73 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.
in vitro Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells[1]. Cinnamic acid (tCA) upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by Cinnamic acid[2].
in vivo In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Thus, cinnamic acid exhibits a low toxicity[1]. Cinnamic acid could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 HT-144
濃度 0.0125 to 3.2 mM
反応時間 48 h
実験の流れ Briefly, 1 × 104 cells are seeded in each well containing 100 μL of DMEM plus 10% of FBS in a 96-well plate. After 24 h, various concentrations of cinnamic acid are added. The control group receives rug-free medium. After 2 days, 15 μL of "Dye Solution" are added to each well and the plates were incubated for additional 4 h. Then, 100 μL of “Solubilization/Stop Solution” are added in each well and the optical density is measured at 570 nm
動物実験 動物モデル BALB/c nude mice
投薬量 1.0 and 1.5 mmol/kg
投与方法 intragastrically administered

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Cinnamic acid inhibits cell viability, invasion, and glycolysis in primary endometrial stromal cells by suppressing NF-κB-induced transcription of PKM2 [ Biosci Rep, 2021, BSR20211828] PubMed: 34499120

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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