Ciprofloxacin

製品コードS2027 バッチS202701

印刷

化学情報

Synonyms

Bay o 9867,Bay q 3939

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₇H₁₈FN₃O₃

分子量

331.34

CAS No.

85721-33-1

Solubility (25°C)*

体外

0.5MNAOH

3 mg/mL (9.05 mM)

DMSO

Insoluble

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Clear solution	5%0.1MNaOH 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.15mg/ml (0.45mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified 0.1MNaOH stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% 0.1MNaOH 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.15mg/ml (0.45mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear 0.1MNaOH stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
in vitro	Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. ^[1] This compound inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. ^[2] It shows an AUC (area under the curve) of 24 μg×h/ml^[3]

製品説明

Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

in vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. ^[1] This compound inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. ^[2] It shows an AUC (area under the curve) of 24 μg×h/ml^[3]

プロトコル(参考用のみ)

キナーゼアッセイ	minimal inhibitory concentration
キナーゼアッセイ	The antimicrobial activities of the compounds are determined by an agar plate dilution method in which Iso-Sensitest agar (pH 7.2) is supplemented with 5% lysed human blood to support the growth of Bacteroides fragilis, 10% whole human blood to support the growth of streptococci (including pneumococci), a Levinthal preparation to support the growth of Haemophilus influenzae, and a chocolate agar to support the growth of Neisseria gonorrhoeae. The organisms are grown overnight in nutrient broth yielding a viable count of about 10⁹ CFU/ml. All plates are incubated in air at 37°C for 24 h, except the anaerobes, which are incubated in a GasPak jar. The minimal inhibitory concentration (MIC) of this compound is defined as the concentration (in micrograms per milliliter of medium) at which there is an estimated 99% reduction (by counting) in the original inoculum. A slight haze of growth in the case of the higher inoculum is ignored.

参考

https://pubmed.ncbi.nlm.nih.gov/6222695/
https://pubmed.ncbi.nlm.nih.gov/8891138/
https://pubmed.ncbi.nlm.nih.gov/10049286/

カスタマーフィードバック

: Data from [Cancer Res, 2012, 72(23), 6200-8]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting Intracellular Mycobacteria Using Nanosized Niosomes Loaded with Antibacterial Agents [ Nanomaterials (Basel), 2021, 11(8)1984]	PubMed: 34443815
Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy [ Environ Mol Mutagen, 2019, 60(6):513-533]	PubMed: 30702769

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。