Ciprofloxacin

製品コードS2027 バッチS202701

化学情報

	Synonyms	Bay o 9867,Bay q 3939	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₇H₁₈FN₃O₃
	分子量	331.34	CAS No.	85721-33-1
Solubility (25°C)*	体外	0.5MNAOH	3 mg/mL (9.05 mM)
		DMSO	Insoluble
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.
in vitro	Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. ^[1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. ^[2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml^[3]

製品説明

Ciprofloxacin (Bay o 9867,Bay q 3939) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

in vitro

Ciprofloxacin is a fluoroquinolone antibiotic, shows MIC90 (minimal inhibitory concentrations for 90%) of between 0.008 and 2 μg/ml for Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, streptococci, Staphylococcus aureus, and Bacteroidesfragilis strains. ^[1] Ciprofloxacin inhibits topoisomerase IV as a primary topoisomerase target and gyrase as a secondary target. ^[2] Ciprofloxacin shows an AUC (area under the curve) of 24 μg×h/ml^[3]

プロトコル(参考用のみ)

キナーゼアッセイ	minimal inhibitory concentration
キナーゼアッセイ	The antimicrobial activities of the compounds are determined by an agar plate dilution method in which Iso-Sensitest agar (pH 7.2) is supplemented with 5% lysed human blood to support the growth of Bacteroides fragilis, 10% whole human blood to support the growth of streptococci (including pneumococci), a Levinthal preparation to support the growth of Haemophilus influenzae, and a chocolate agar to support the growth of Neisseria gonorrhoeae. The organisms are grown overnight in nutrient broth yielding a viable count of about 10⁹ CFU/ml. All plates are incubated in air at 37癈 for 24 h, except the anaerobes, which are incubated in a GasPak jar, the minimal inhibitory concentration (MIC) of the antibiotic is defined as the concentration (in micrograms per milliter of medium) at which there is an estimated 99%/ reduction (by counting) in the original inoculum. A slight haze of growth in the case of the higher inoculum is ignored.

参考

カスタマーフィードバック

: Data from [Cancer Res, 2012, 72(23), 6200-8]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting Intracellular Mycobacteria Using Nanosized Niosomes Loaded with Antibacterial Agents [ Nanomaterials (Basel), 2021, 11(8)1984]	PubMed: 34443815
Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy [ Environ Mol Mutagen, 2019, 60(6):513-533]	PubMed: 30702769

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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