Cisapride (R 51619)

製品コードS5253 バッチS525301

化学情報

	Synonyms	Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₃H₂₉ClFN₃O₄
	分子量	465.95	CAS No.	81098-60-4
Solubility (25°C)*	体外	DMSO	93 mg/mL (199.59 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.
in vitro	Cisapride is a 5-HT4 receptor agonist, also a hERG blockers^[1]. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist^[2].

製品説明

Cisapride (R 51619, Kaudalit, Kinestase, Prepulsid, Presid, Pridesia, Propulsid) is a nonselective 5-HT4 receptor agonist with gastroprokinetic effects.

in vitro

Cisapride is a 5-HT4 receptor agonist, also a hERG blockers^[1]. It is widely used for the treatment of gastrointestinal motility dysfunctions, such as gastroesophageal reflux disorder (GERD), chronic intestinal pseudo-obstruction, and slow-transit constipation gastroparesis. Cisapride works by promoting gastrointestinal motility through stimulating the release of intestinal acetylcholine from muscarinic receptors. Cisapride inhibits Kv 4.3 channels that are stably expressed in Chinese hamster ovary (CEO) cells as well as the current in L-type Ca2+ channels of ventricular myocytes. Cisapride inhibited Kv channel current in a concentration-dependent manner independent of its own function as a selective serotonin 5-HT4-receptor agonist^[2].

プロトコル(参考用のみ)

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。