Citral

製品コードS5138 バッチS513801

印刷

化学情報

Chemical Structure Synonyms Geranialdehyde Storage
(From the date of receipt)		 2 years -80°C liquid
化学式

C10H16O
分子量 152.23 CAS No. 5392-40-5
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.
密度 0.888 g/mL at 25 °C

生物活性

製品説明 Citral (Geranialdehyde) is an α,β-unsaturated aldehyde present in the oils of several plants. It is an aroma compound used in perfumery for its citrus effect and is also used as a flavor and for fortifying lemon oil.
in vitro Citral is the mixture of two isomeric acyclic monoterpene aldehydes, the trans-isomer geranial or citral A and the cis-isomer neral or citral B. Several pharmacological activities of citral have been documented such as anti-inflammatory effects, antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi, and some protozoa, and anticancer activities against some cancer cell lines including leukemic, breast, and lymphoma cells. Treatment with citral results in an activation of caspase-3, leading to apoptosis in human U937, HL60, and NB4 and mouse RL12 and BS-24-1 leukemic cell lines. Moreover, it inhibits human breast cancer cell MCF-7 growth and induces cycle arrest in G2/M phase. Citral induces human lymphoma Ramos cell apoptosis by activating caspase activity in a concentration and time-dependent manner but has no effect on cell distribution in the cell cycle[1].
in vivo Citral can block the L-type calcium channels and shows a significant anti-inflammatory effect in the carrageenan model. It has a very important anti-inflammatory activity in the test of croton oil-induced ear edema in mice[2]. Treatment with citral oil in mice with lung injury induced by LPS inhibits TNF-α, IL-1β, and IL-6 levels both in vivo and in vitro[3].
密度 0.888 g/mL at 25 °C

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Ramos and PBMCs
濃度 10, 20, and 40 μM
反応時間 24 h
実験の流れ

Ramos and PBMCs (1 × 106 cells/ml) are also treated with doxorubicin in combination with citral (10, 20, and 40 µM) for 24 h at 37 °C. Cytotoxicity of treated cells is determined by adding 5 µl of 1 mg/ml resazurin solution in each well.
動物実験 動物モデル Virgin female Wistar rats aged 7-9 weeks
投薬量 100-800 mg/kg
投与方法 oral

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。