CNO (Clozapine N-oxide)

製品コードS6887 バッチS688701

印刷

化学情報

Chemical Structure Synonyms Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C18H19ClN4O
分子量 342.82 CAS No. 34233-69-7
Solubility (25°C)* 体外 DMSO 68 mg/mL (198.35 mM)
Water (warmed with 50ºC water bath) 68 mg/mL (198.35 mM)
Ethanol 8 mg/mL (23.33 mM)
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.
in vitro

CNO is a synthetic small molecule actuator for muscarinic acetylcholine DREADDs.
in vivo

Clozapine N-oxide (CNO), an agonist of human muscarinic designer receptor (DREADDs), is converted to clozapine and exerts clozapine-like behavioral effects in both mice and rats further emphasizes the need for appropriate control groups in studies employing DREADDs.[4]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 CHO cells
濃度 pEC50 8.31
反応時間
実験の流れ
動物実験 動物モデル standard laboratory rats and mice
投薬量 1.0, 3.2, 10.0 mg/kg for rats; 1.25, 2.5, 5.0, 10.0, 20.0 mg/kg for mice
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/29497149/
  • https://pubmed.ncbi.nlm.nih.gov/31214037/
  • https://pubmed.ncbi.nlm.nih.gov/7895765/
  • https://pubmed.ncbi.nlm.nih.gov/29497149/
  • https://pubmed.ncbi.nlm.nih.gov/30038895/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Glutamatergic pathways from medial prefrontal cortex to paraventricular nucleus of thalamus contribute to the methamphetamine-induced conditioned place preference without affecting wakefulness [ Theranostics, 2025, 15(5):1822-1841] PubMed: 39897554
Protocol to study the role of medial entorhinal cortex-basolateral amygdala circuit in context-induced retrieval of morphine withdrawal memory in mice [ STAR Protoc, 2025, 6(1):103542] PubMed: 39921862
Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference [ Theranostics, 2024, 14(7):2881-2896] PubMed: 38773977
Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference [ Theranostics, 2024, 14(7):2881-2896] PubMed: 38773977
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation [ Cell Rep, 2024, 43(8):114529] PubMed: 39046876
Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory [ iScience, 2024, 27(7):110239] PubMed: 39021787
Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion [ Nat Commun, 2023, 10.1038/s41467-023-42814-1] PubMed: 37903803
Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice [ Nat Commun, 2023, 14(1):71] PubMed: 36604429
Stress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion [ Nat Commun, 2023, 14(1):6923] PubMed: 37903803
Tet2 acts in the lateral habenula to regulate social preference in mice [ Cell Rep, 2023, 42(7):112695] PubMed: 37402169

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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