Colivelin

製品コードS9664 バッチS966401

印刷

化学情報

Synonyms

CLN

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₁₉H₂₀₆N₃₂O₃₅

分子量

2645.10

CAS No.

867021-83-8

Solubility (25°C)*

体外

DMSO

100 mg/mL (37.8 mM)

Water

100 mg/mL (37.8 mM)

体内（毎回新しく調製した物を用意してください）

Clear solution

5% H2O 1 40% PEG 300 2 5% Tween 80 3 ddH2O

この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。

5.000mg/ml (1.89mM)

Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified H2O stock solution to 400 μL of PEG 300, mix evenly to clarify; add 50 μL of Tween 80 to the above system, mix evenly to clarify; Then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.
in vitro	Colivelin, a brain penetrant neuroprotective peptide, significantly increases the p-STAT3 protein levels in BV-2 cells.^[2]
in vivo	This compound protects against ischemic brain injury and improves neurological outcomes, by elevating anti-apoptotic genes up-regulation and activates JAK/STAT3 signaling afetr ischemic stroke.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BV-2 cells
	濃度	50 µg/ml
	反応時間	4 h
	実験の流れ	BV-2 cells are maintained at 37℃ with 5% CO₂. To build OGD models, BV-2 cells are washed with PBS for 3 times, and cultured in glucose-free DMEN and placed in a hypoxia incubation chamber filled with the gas mixture for 4 h at 37℃. The culture medium is then replaced by the normal medium containing 4.5 g/L glucose and cells are cultured under normoxic conditions for reoxygenation for 24 h. BV-2 cells are treated with 50 µg/ml rmMFG-E8 or/and this compound, respectively. The expression changes of proteins (p-STAT3 and SOCS3) are analyzed by Western blot assay.
動物実験	動物モデル	Male C57BL/6 mice of middle cerebral artery occlusion (MCAO) models
	投薬量	1 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/31374230/
https://pubmed.ncbi.nlm.nih.gov/32098538/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs [ J Clin Invest, 2025, 135(11)e181243]	PubMed: 40179015
Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization [ J Adv Res, 2025, S2090-1232(25)00444-8]	PubMed: 40533059
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy [ Stem Cell Res Ther, 2025, 16(1):40]	PubMed: 39901236
Intracellular CIRP promotes liver regeneration via STAT3 signaling pathway activation after partial hepatectomy in mice [ Int J Mol Med, 2025, 55(3)42]	PubMed: 39791211
CLCF1 contributes to high-glucose-induced EndMT by modulating JAK2/STAT3 signaling [ Eur J Med Res, 2025, 30(1):682]	PubMed: 40731368
THBS1 knockdown suppresses pancreatic cancer progression through JAK2/STAT3 signaling pathway [ Mol Cell Probes, 2025, 79:102003]	PubMed: 39710065
p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production [ Commun Biol, 2024, 7(1):999]	PubMed: 39147860
Efficacy of nintedanib as a host-directed therapy candidate in the treatment of tuberculosis [ J Antimicrob Chemother, 2024, dkae429]	PubMed: 39656809
HOXB5 promotes the progression and metastasis of osteosarcoma cells by activating the JAK2/STAT3 signalling pathway [ Heliyon, 2024, 10(9):e30445]	PubMed: 38737261
Intracellular CIRP promotes liver regeneration while extracellular CIRP induces ER stress after partial hepatectomy in mice [ Research Square, 2024, 10.21203/rs.3.rs-3840462/v1]	PubMed: none

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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