CORM-3

製品コードS7448 バッチS744801

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C5 H4 Cl N O5 Ru
分子量 294.61 CAS No. 475473-26-8
Solubility (25°C)* 体外 DMSO 38 mg/mL (128.98 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 CORM-3は、抗炎症作用と心臓保護作用を持つ一酸化炭素放出分子です。
in vitro CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. This compound attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. It also uncouples mitochondrial respiration via interaction with the phosphate carrier.
in vivo CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. This compound (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model.

プロトコル(参考用のみ)

動物実験 動物モデル CBA mice transplanted with BALB/c hearts.
投薬量 ~40 mg/kg daily
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/12842916/
  • https://pubmed.ncbi.nlm.nih.gov/15880142/
  • https://pubmed.ncbi.nlm.nih.gov/18063671/
  • https://pubmed.ncbi.nlm.nih.gov/24161358/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer [ Cell Death Discov, 2024, 10(1):42] PubMed: 38263152
CORM-3 exerts a neuroprotective effect in a rodent model of traumatic brain injury via the bidirectional gut-brain interactions [ Exp Neurol, 2021, 341:113683] PubMed: 33711325
Carbon Monoxide-Releasing Molecule-3 Alleviates Kupffer Cell Pyroptosis Induced by Hemorrhagic Shock and Resuscitation via sGC-cGMP Signal Pathway [ Inflammation, 2021, 10.1007/s10753-021-01419-w] PubMed: 33575924
Carbon Monoxide-Releasing Molecule-3 Ameliorates Acute Lung Injury in a Model of Hemorrhagic Shock and Resuscitation: Roles of p38MAPK Signaling Pathway [ Shock, 2021, 55(6):816-826] PubMed: 33105439
Carbon monoxide releasing molecule-3 alleviates neuron death after spinal cord injury via inflammasome regulation [Zheng G EBioMedicine, 2019, 10.1016/j.ebiom.2018.12.059] PubMed: 30612943
Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation. [ Free Radic Biol Med, 2019, 141:299-309] PubMed: 31265876
A fluorescent probe for carbon monoxide based on allyl ether rather than allyl ester: A practical strategy to avoid the interference of esterase in cell imaging. [ Talanta, 2019, 205:120070] PubMed: 31450480

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。