Curcumenol

製品コードS3874 バッチS387402

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₅H₂₂O₂
	分子量	234.33	CAS No.	19431-84-6
Solubility (25°C)*	体外	DMSO	47 mg/mL (200.57 mM)
		Ethanol	47 mg/mL (200.57 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.
in vitro	Curcumenol markedly decreases LPS-induced production of nitric oxide (NO), pro-inflammatory cytokines [(IL-6) and (TNF-α)] and pro-inflammatory proteins expression, iNOS and COX-2. Curcumenol has also been shown to exhibit hepatoprotective properties. Curcumenol can suppress the LPS-induced NF-κB activity by inhibiting the phosphorylation of Akt. Its treatment significantly inhibits LPS-induced phosphorylation of p38 MAPK but not JNK and ERK^[1]. The activity of CYP3A4 is strongly inhibited by curcumenol with an IC50 value of 12.6 ± 1.3 μM. Kinetic analysis shows curcumenol competitively inhibits testosterone 6β-hydroxylation activity (CYP3A4) with Ki of 10.8 μM^[2].

製品説明

Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.

in vitro

Curcumenol markedly decreases LPS-induced production of nitric oxide (NO), pro-inflammatory cytokines [(IL-6) and (TNF-α)] and pro-inflammatory proteins expression, iNOS and COX-2. Curcumenol has also been shown to exhibit hepatoprotective properties. Curcumenol can suppress the LPS-induced NF-κB activity by inhibiting the phosphorylation of Akt. Its treatment significantly inhibits LPS-induced phosphorylation of p38 MAPK but not JNK and ERK^[1]. The activity of CYP3A4 is strongly inhibited by curcumenol with an IC50 value of 12.6 ± 1.3 μM. Kinetic analysis shows curcumenol competitively inhibits testosterone 6β-hydroxylation activity (CYP3A4) with Ki of 10.8 μM^[2].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BV-2 cell line
	濃度	2.5–20 μM
	反応時間	2 h
	実験の流れ	BV-2 cells are seeded into a sterile flat bottom 96-well plate. The cells are then allowed to adhere overnight. The cells are pretreated with various concentrations of curcumenol for 2 h followed by LPS exposure (0.4 μg/mL) for 12 h to 24 h.

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFα/NFκB Pathway [ Front Pharmacol, 2022, 13:905966]	PubMed: 35795557
An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX-Induced Osteoporosis in Mice [ J Bone Miner Res, 2021, 10.1002/jbmr.4328]	PubMed: 33956362
Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice [ Int J Mol Med, 2021, 48(4)192]	PubMed: 34435650

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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