受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C20H28N6O3 |
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分子量 | 400.47 | CAS No. | 199986-75-9 | |
Solubility (25°C)* | 体外 | DMSO | 80 mg/mL (199.76 mM) | |
Ethanol | 80 mg/mL (199.76 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases. |
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in vitro | In cells exposed to CVT-313, hyperphosphorylation of the retinoblastoma gene product is inhibited, and progression through the cell cycle is arrested at the G1/S boundary. The growth of mouse, rat, and human cells in culture is also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 μM. CVT-313 inhibits Rb hyperphosphorylation[1]. |
細胞アッセイ | 細胞株 | MRC-5 cells |
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濃度 | 12.5 μM | |
反応時間 | 24 h | |
実験の流れ | -- |
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動物実験 | 動物モデル | Rat carotid artery model of restenosis |
投薬量 | 0.025, 0.25, 0.75, 1.25 mg/kg | |
投与方法 | intraluminal |
The MYBL2-CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages [ Cancer Cell Int, 2023, 10.1186/s12935-023-03079-2] | PubMed: 37865750 |
The MYBL2-CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages [ Cancer Cell Int, 2023, 23(1):248] | PubMed: 37865750 |
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer [ Cell Rep, 2022, 40(7):111218] | PubMed: 35977518 |
Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway [ Biomedicines, 2022, 10(8)2012] | PubMed: 36009559 |
Dbf4-Cdc7 (DDK) InhibitorPHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway [ Biomedicines, 2022, 10(8)2012] | PubMed: 36009559 |
Genetic vulnerabilities upon inhibition of DNA damage response [ Nucleic Acids Res, 2021, gkab643] | PubMed: 34320214 |
Non-metabolic function of MTHFD2 activates CDK2 in bladder cancer [ Cancer Sci, 2021, 112(12):4909-4919] | PubMed: 34632667 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。