Cyclandelate

製品コードS4189 バッチS418901

印刷

化学情報

Synonyms

BS 572,3,5,5-Trimethylcyclohexyl mandelate

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₇H₂₄O₃

分子量

276.37

CAS No.

456-59-7

Solubility (25°C)*

体外

DMSO

55 mg/mL (199.0 mM)

Ethanol

55 mg/mL (199.0 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
in vitro	Cyclandelate is a direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. This compound is in a class of drugs called vasodilators. It relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. This chemical produces peripheral vasodilation by a direct effect on vascular smooth muscle. Its pharmacological action may be due to calcium-channel antagonism. ^[1] It is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. This agent hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester. ^[2]

製品説明

Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.

in vitro

Cyclandelate is a direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. This compound is in a class of drugs called vasodilators. It relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. This chemical produces peripheral vasodilation by a direct effect on vascular smooth muscle. Its pharmacological action may be due to calcium-channel antagonism. ^[1] It is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. This agent hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester. ^[2]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/3622309/
https://pubmed.ncbi.nlm.nih.gov/2306268/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。