Cysteamine HCl

製品コードS4206 バッチS420601

印刷

化学情報

Synonyms

Mercaptamine

Storage
(From the date of receipt)

3 years -20°C powder (seal)

化学式

C₂H₇NS.HCl

分子量

113.61

CAS No.

156-57-0

Solubility (25°C)*

体外

DMSO

23 mg/mL (202.44 mM)

Water

23 mg/mL (202.44 mM)

Ethanol

23 mg/mL (202.44 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.15mg/ml (10.12mM)	Taking the 1 mL working solution as an example, add 50 μL of 23 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.16mg/ml (1.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 3.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cysteamine(Mercaptamine) is an agent for the treatment of nephropathic cystinosis and an antioxidant.Cysteamine HCl can be used to induce animal models of Duodenal Ulcer.
in vitro	Cysteamine HCl has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by this compound administration. It has antioxidant properties as a result of increasing glutathione production. This chemical is an excellent scavenger of ^OH and HOCl; it also reacts with H₂O₂. This agent increases the production of several heat shock proteins (HSP), including the murine Hsp40. It exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas this compound treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of this chemical to doxorubicin results in a dramatic increase in cell death. ^[1] This compound (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes. ^[2]
in vivo	Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. This compound can inhibit transglutaminase activity by binding to the cysteine in its active center. It increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). This chemical inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of this compound is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. ^[1]

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/23416144/
https://pubmed.ncbi.nlm.nih.gov/8607972/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury [ Nat Commun, 2023, 14(1):7598]	PubMed: 37990003
Nanocarriers Based on Gold Nanoparticles for Epigallocatechin Gallate Delivery in Cancer Cells [ Pharmaceutics, 2022, 14(3)491]	PubMed: 35335868

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。