Cytosporone B

製品コードS6674 バッチS667402

印刷

化学情報

Synonyms

Csn-B

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₈H₂₆O₅

分子量

322.40

CAS No.

321661-62-5

Solubility (25°C)*

体外

DMSO

64 mg/mL (198.51 mM)

Ethanol

64 mg/mL (198.51 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	2%DMSO 1 40% PEG 300 2 5%Tween80 3 53%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.000mg/ml (3.10mM)	Taking the 1 mL working solution as an example, add 20 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 530 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Cytosporone B is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278 nM.
in vitro	Cytosporone B effectively decreases the TGF-β1-dependent elevated expression of fibrotic markers in vitro.^[2]
in vivo	Cytosporone B, an NR4A1 agonist, effectively suppresses fibrogenesis in mouse endometriotic tissue.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human ectopic endometrial stromal cells (EESCs), normal endometrial stromal cells (NESCs)
	濃度	1 μM
	反応時間	24 h
	実験の流れ	After being incubated with Csn-B (1 μmol), siRNA, and TGF-β1 for 24 h, total RNA from cells is extracted with TRIzol reagent for PCR analysis. Proteins from cells Are extracted for Western blot analysis.
動物実験	動物モデル	Nude mouse model of endometriosis
	投薬量	13 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/18690216/
https://pubmed.ncbi.nlm.nih.gov/29669342/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

NR4A1 suppresses breast cancer growth by repressing c-Fos-mediated lipid and redox dyshomeostasis [ Exp Mol Med, 2025, 57(4):804-819]	PubMed: 40164686
Nur77 attenuates Paneth cell necroptosis-induced intestinal inflammation through regulating endoplasmic reticulum homeostasis in sepsis [ J Adv Res, 2025, S2090-1232(25)00582-X]	PubMed: 40749794
Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation [ Mol Med, 2023, 29(1):63]	PubMed: 37161357
Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation [ Mol Med, 2023, 29(1):63]	PubMed: 37161357
FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression [ Signal Transduct Target Ther, 2021, 6(1):133]	PubMed: 33762571
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy [ J Pineal Res, 2018, 64(1)]	PubMed: 28981157
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy [ J Pineal Res, 2018, 64(1)]	PubMed: 28981157
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis. [ Cell Physiol Biochem, 2018, 46(3):1078-1090]	PubMed: 29669342

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。