D-Aspartic acid

製品コードS5129 バッチS512901

印刷

化学情報

Chemical Structure Synonyms Asp, Aminosuccinic acid, asparagic acid, asparaginic acid Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C4H7NO4
分子量 133.10 CAS No. 1783-96-6
Solubility (25°C)* 体外 5%TFA 6.02 mg/mL (45.22 mM)
DMSO 0.01 mg/mL (0.07 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).
in vitro D-aspartate (D-Asp) is an endogenous amino acid present in vertebrate tissues, with particularly high levels in the testis. In vitro studies have demonstrated that D-Asp up-regulates testosterone production in Leydig cells by enhancing expression of the steroidogenic acute regulatory protein. Besides testosterone release, D-Asp induced E2 synthesis through aromatase activation[1].
in vivo In vivo studies indicate that D-Asp indirectly stimulates spermatogenesis through the hypothalamic-pituitary-gonadal axis. The oral and/or intraperitoneal D-Asp administration to adult rats induced an increase of serum progesterone and LH as well as an increase of testis/serum testosterone levels, whereas 17β-estradiol (E2) levels did no change[1]. D-aspartic acid has significant analgesic activity[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 GC-1 cells
濃度 200 μM
反応時間 30 min, 2 h, 4 h
実験の流れ

Cultures were carried on in the presence of D-Asp (200 μM; diluted in distilled H2O) in different time exposure of the amino acid (30 min, 2 h, 4 h). Control cultures were treated with vehicle alone. At the end of the incubation period, cells were rinsed in PBS, harvested by trypsinization, collected by centrifugation at 1,000g for 10 min and immediately frozen at  80°C for biochemical analyses.
動物実験 動物モデル Inbred albino BALB/C mice
投薬量 55, 115, and 230 mg/kg
投与方法 i.p.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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