D-Pinitol

製品コードS3870 バッチS387001

印刷

化学情報

Chemical Structure Synonyms Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C7H14O6
分子量 194.18 CAS No. 10284-63-6
Solubility (25°C)* 体外 DMSO 38 mg/mL (195.69 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 D-pinitol (Methylinositol, Pinitol, 3-O-Methyl-D-chiro-inositol, D-(+)-Pinitol, Inzitol) is a naturally occurring compound derived from soy and has significant pharmacological activitites such as inhibition of the T-helpercell-1 response, antiviral, larvicidal, antiinflammatory, antihyperlipidemic, cardioprotective, inhibition of ovalbumin-induced airway inflammation and antioxidant.
in vitro D-pinitol reduces the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Treatment of prostate cancer cells with D-pinitol reduces mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerts its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-κB activation[1].
in vivo D-pinitol exerts an acute and chronically-sustained antihyperglycaemic effect in the murine STZ-induced model of hypoinsulinaemic diabetes. The mechanism of action of D-pinitol does not augment the effect of insulin but might involve an interaction with part of a cellular signalling pathway that links insulin with glucose transport[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Human prostate cancer cell lines (PC3 and DU145)
濃度 0, 1, 3, 10 and 30 μM
反応時間 24 h
実験の流れ For invasion assay, filters are precoated with 30 μL Matrigel basement membrane matrix for 30 min. The following procedures are the same for both migration and invasion assays. After the treatment with D-pinitol (0, 1, 3, 10 and 30 μM) for 24 h, cells are harvested and seeded to Transwell at 1 × 104 cells/well in serum-free medium and then incubated for 24 h at 37 °C in 5% CO2. Cells are then fixed in 3.7% formaldehyde for 5 min and stained with 0.05% crystal violet in PBS for 15 min. Cells on the upper side of the filters are removed with cotton-tipped swabs, and the filters are washed with PBS. Cells on the underside of the filters are examined and counted under a microscope.
動物実験 動物モデル Obese-diabetic ob/ob mice
投薬量 up to 100 mg/kg
投与方法 p.o./i.p.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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