Deferoxamine mesylate

製品コードS5742 バッチS574209

印刷

化学情報

Chemical Structure Synonyms Ba 33112, Desferrioxamine B, DFOM, NSC 644468, DFO Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C26H52N6O11S
分子量 656.79 CAS No. 138-14-7
Solubility (25°C)* 体外 Water 100 mg/mL (152.25 mM)
DMSO 50 mg/mL (76.12 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.
in vitro

Deferoxamine mesylate, the iron chelator and ferroptosis inhibitor, rescues neutrophil death induced by systemic lupus erythematosus (SLE) serum, suggesting that ferroptosis may be the main form of neutrophil death in SLE.[3]
in vivo

Deferoxamine mesylate (Ba 33112, Desferrioxamine B, DFOM, NSC 644468) is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent.

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Healthy neutrophil cell
濃度 1/10/100 μM
反応時間 16 h
実験の流れ

Cells are cultured in complete RPMI 1640 basic medium (Gibco) with 100 U/ml penicillin, 100 μg/ml streptomycin and 20% serum from ten randomly selected patients with SLE or age- and sex-matched healthy controls (HCs), and incubated at 37 ℃ in a humidified atmosphere of 20% O2 and 5% CO2. HC neutrophil cell viability treated with two ferroptosis inhibitors, LPX-1 (10/100/1,000 nM) or DFO (1/10/100 μM), two necroptosis inhibitors, Nec-1 (10/100/1,000 nM) or NSA (10/100/1,000 nM), or apoptosis inhibitor Z-VAD (0.1/1/10 μM) for 16 h are assessed by flow cytometry.
動物実験 動物モデル Mongrel dogs
投薬量 25 mg/kg
投与方法 i.m.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development [ Cell Rep Med, 2024, 5(3):101476] PubMed: 38508138
Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis [ Redox Biol, 2024, 69:103008] PubMed: 38142586
Silica nanoparticles induce ferroptosis of HUVECs by triggering NCOA4-mediated ferritinophagy [ Ecotoxicol Environ Saf, 2024, 270:115889] PubMed: 38150751
Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells [ J Virol, 2024, 98(3):e0189723] PubMed: 38411946
The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease [ Hepatol Commun, 2024, 8(3)e0396] PubMed: 38437058
Berberine-mediated Ferroptosis through System Xc-/GSH/GPX4 Axis Inhibits Metastasis of Nasopharyngeal Carcinoma [ J Cancer, 2024, 15(3):685-698] PubMed: 38213727
Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis [ Sci Adv, 2024, 10(11):eadk7329] PubMed: 38489367
LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia [ J Hematol Oncol, 2023, 16(1):30] PubMed: 36973755
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease [ Mil Med Res, 2023, 10.1186/s40779-023-00487-3] PubMed: 37941054
Ferroptosis-Enhanced Immunotherapy with an Injectable Dextran-Chitosan Hydrogel for the Treatment of Malignant Ascites in Hepatocellular Carcinoma [ Adv Sci (Weinh), 2023, 10(20):e2300517] PubMed: 37132587

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。