Denosumab (anti-RANK ligand)

製品コード：A2020         Batch: A202004

印刷

Denosumab (anti-RANK ligand) (AMG-162, Prolia, Xgeva) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

製品説明

CAS No. 615258-40-7
Formulation PBS Buffer, pH 7.4
Isotype human IgG4
Source HEK293
Storage
(From the date of receipt)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Shipping Shipped under low temperature conditions
Purity 99%
Protein concentration 17.05mg/ml
Endotoxin Level ＜1EU/mg

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression [ ACS Omega, 2023, 8(23):20739-20754] PubMed: 37323396

人間や獣医の診断であるか治療的な使用のためにでない。