Denosumab (anti-RANK ligand)

製品コード：A2020 Batch: A202005

Denosumab (anti-RANK ligand) (AMG-162) is a fully human monoclonal antibody that selectively inhibits primate RANKL. Denosumab inhibits the ability of human RANKL (143–317) to stimulate the formation of osteoclasts derived from murine RAW 264.7 cells with an IC50 value of 1.64 nM.

製品説明

CAS No.	615258-40-7
Formulation	PBS Buffer, pH 7.4
Isotype	human IgG1
Source	HEK293
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
Shipping	Shipped under low temperature conditions
Purity	99%
Protein concentration	7.45 mg/ml
Endotoxin Level	＜1EU/mg

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Protocol for constructing in vivo and in vitro models integrating clinical and proteomic subtypes of chordoma [ STAR Protoc, 2025, 6(2):103719]	PubMed: 40156836
Clinical-proteomic classification and precision treatment strategy of chordoma [ Cell Rep Med, 2024, 5(10):101757]	PubMed: 39368483
TNFSF11/TNFRSF11A Axis Amplifies HDM-Induced Airway Remodeling by Strengthening TGFβ1/STAT3 Action [ Allergy Asthma Immunol Res, 2024, 16(4):399-421]	PubMed: 39155739
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression [ ACS Omega, 2023, 8(23):20739-20754]	PubMed: 37323396

人間や獣医の診断であるか治療的な使用のためにでない。