Diacerein

製品コードS4267 バッチS426702

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C19H12O8
分子量 368.29 CAS No. 13739-02-1
Solubility (25°C)* 体外 DMSO 18 mg/mL (48.87 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Diacerein is an inhibitor of pro-inflammatory cytokine Interleukin-1B (IL-1B) production, prescribed for osteoarthritis and chronic inflammatory arthritis.
in vitro Diacerein significantly inhibits LPS-induced IL-1beta production by synovial tissue and cartilage. This compound (1 μM) has a significantly less inhibitory effect on cartilage synthesis than culture media containing LPS only. It decreases NO release in synovial tissue and cartilage media and increases IL-1ra levels in cartilage culture media. [1] This chemical (10 μM) enhances the expression of TGF-beta1 and TGF-beta2 in cultured bovine articular chondrocytes. [2] It reduces, in a dose-dependent manner, the interleukin-1-beta (IL-1beta)-induced MMP-13 production in osteoarthritic subchondral bone. This agent significantly reduces the activity of MMP-13 and cathepsin K in osteoclasts. It effectively blocks the IL-1beta effect on the osteoclast differentiation process and the survival of mature osteoclasts. [3]
in vivo Diacerein (100 mg/kg/day) significantly suppresses the paw edema and the increase in serum mucoprotein in the adjuvant-induced arthritic rats. This compound (30 mg/kg/day) combined with Naproxen (3 mg/kg/day) results in significantly greater anti-inflammatory activity than with naproxen alone in the adjuvant-induced arthritic rats. It (100 mg/kg/day) also significantly prevents bone loss and reduces the serum alkaline phosphatase and decreases the excretion of urinary hydroxyproline in the ovariectomized rats. [4] This chemical (25 mg/kg) decreases the thickness of cartilage and subchondral bone in the lesion (middle) zone of the lateral tibial plateau in Merino wethers. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10329302/
  • https://pubmed.ncbi.nlm.nih.gov/10329300/
  • https://pubmed.ncbi.nlm.nih.gov/18578867/
  • https://pubmed.ncbi.nlm.nih.gov/12126975/
  • https://pubmed.ncbi.nlm.nih.gov/11327258/

カスタマーフィードバック

, , J Neuroinflammation, 2016, 13(1):183.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Autophagy-mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization [ MedComm (2020), 2024, 5(8):e668] PubMed: 39081514
Combination of hyperlipidemia and 17β-Estradiol induces TMJOA-like pathological changes in rats [ Oral Dis, 2022, 10.1111/odi.14294] PubMed: 35765240
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia [ Free Radic Biol Med, 2021, 165:171-183] PubMed: 33515754
Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor [ Cancer Res, 2020, canres.530.2020] PubMed: 32571799
Small molecule inhibitor of TAK1 ameliorates rat cartilaginous endplate degeneration induced by oxidative stress in vitro and in vivo. [ Free Radic Biol Med, 2020, 148:140-150] PubMed: 31911149
Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice [Zhang Q, et al. J Neuroinflammation, 2016, 13(1):183] PubMed: 27401148

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。