Diammonium Glycyrrhizinate

製品コードS3622 バッチS362201

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₄₂H₆₂O₁₆. 2H₃N

分子量

856.99

CAS No.

79165-06-3

Solubility (25°C)*

体外

DMSO

100 mg/mL (116.68 mM)

Water

100 mg/mL (116.68 mM)

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	5.000mg/ml (5.83mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.625mg/ml (0.73mM)	Taking the 1 mL working solution as an example, add 50 μL of 12.5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	伝統的な漢方薬(TCM)であるDiammonium Glycyrrhizinate(DG)は、甘草(Radix glycyrrhizae)から抽出・精製されます。抗炎症作用、生物学的酸化に対する耐性、膜保護作用があることが知られています。DGは、NF-κB、TNF-α、細胞間接着分子1の抑制を介して炎症性傷害を軽減することができます。
in vivo	Intraperitoneal administration of DG protects mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells is significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 is improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way. DG is able to reduce inflammatory injury via suppression of nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB), tumor necrosis factor‑α and intercellular adhesion molecule 1, which are thought to promote inflammatory injury. DG has neuroprotective potential against ischemia‑reperfusion injury in a model of focal cerebral ischemic‑reperfusion injury.

製品説明

伝統的な漢方薬(TCM)であるDiammonium Glycyrrhizinate(DG)は、甘草(Radix glycyrrhizae)から抽出・精製されます。抗炎症作用、生物学的酸化に対する耐性、膜保護作用があることが知られています。DGは、NF-κB、TNF-α、細胞間接着分子1の抑制を介して炎症性傷害を軽減することができます。

in vivo

Intraperitoneal administration of DG protects mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells is significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 is improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way. DG is able to reduce inflammatory injury via suppression of nuclear factor κ‑light‑chain‑enhancer of activated B cells (NF‑κB), tumor necrosis factor‑α and intercellular adhesion molecule 1, which are thought to promote inflammatory injury. DG has neuroprotective potential against ischemia‑reperfusion injury in a model of focal cerebral ischemic‑reperfusion injury.

プロトコル(参考用のみ)

動物実験	動物モデル	Sprague‑Dawley rats
	投薬量	10 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/17673144/
https://pubmed.ncbi.nlm.nih.gov/18671195/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Diammonium Glycyrrhizinate Exerts Broad-Spectrum Antiviral Activity Against Human Coronaviruses by Interrupting Spike-Mediated Cellular Entry [ Int J Mol Sci, 2025, 26(13)6334]	PubMed: 40650113

Diammonium Glycyrrhizinate Exerts Broad-Spectrum Antiviral Activity Against Human Coronaviruses by Interrupting Spike-Mediated Cellular Entry [ Int J Mol Sci, 2025, 26(13)6334]

PubMed: 40650113

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。