DMF (Dimethyl Fumarate)

製品コードS2586 バッチS258601

印刷

化学情報

Chemical Structure Synonyms BG-12 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C6H8O4
分子量 144.13 CAS No. 624-49-7
Solubility (25°C)* 体外 DMSO 29 mg/mL (201.2 mM)
Ethanol 10 mg/mL (69.38 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 DMF (Dimethyl Fumarate) is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.
in vitro

Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells. [1] Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling. [2] Dimethyl fumarate inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC). [3] Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release. Dimethyl fumarate attenuates CCL2-induced monocyte chemotaxis, suggesting that Dimethyl fumarate could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. [4]
in vivo

Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo. [3] Dimethyl fumarate oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice. [5]

プロトコル(参考用のみ)

カスタマーフィードバック

, , Cancer Biol Ther, 2014, 15(12):1646-57.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects [ Cell Rep Med, 2023, S2666-3791(23)00310-5] PubMed: 37586364
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects [ Cell Rep Med, 2023, 4(9):101157] PubMed: 37586364
Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis [ Cell, 2022, 185(9):1521-1538.e18] PubMed: 35447071
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells [ Mol Cell, 2022, S1097-2765(22)00433-6] PubMed: 35594856
Z-REX uncovers a bifurcation in function of Keap1 paralogs [ Elife, 2022, 11e83373] PubMed: 36300632
Therapeutic Potential of Fingolimod and Dimethyl Fumarate in Non-Small Cell Lung Cancer Preclinical Models [ Int J Mol Sci, 2022, 23(15)8192] PubMed: 35897763
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway [ Front Pharmacol, 2022, 13:872057] PubMed: 35559248
Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway [ J Ethnopharmacol, 2022, 288:115004] PubMed: 35051603
Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis [ Theranostics, 2021, 11(9):4011-4029] PubMed: 33754045
Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma [ Front Pharmacol, 2021 , 12:617714.] PubMed: 33692690

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。