DMF (Dimethyl Fumarate)

製品コードS2586 バッチS258605

印刷

化学情報

Chemical Structure Synonyms BG-12 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C6H8O4
分子量 144.13 CAS No. 624-49-7
Solubility (25°C)* 体外 DMSO 29 mg/mL (201.2 mM)
Ethanol 29 mg/mL (201.2 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 DMF（ジメチル フマル酸）は、フマル酸のメチルエステルであり、多発性硬化症の再発型を患う人々の治療に使用されます。
in vitro

Dimethyl fumarate (DMF) causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells. It inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. This compound impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. It inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling. DMF inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC). As an immune modulator and inducer of the antioxidant response, it suppresses HIV replication and neurotoxin release. It also attenuates CCL2-induced monocyte chemotaxis, suggesting that this compound could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators.

in vivo

Dimethyl fumarate (DMF) inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo. Its oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/22769044/
  • https://pubmed.ncbi.nlm.nih.gov/22733812/
  • https://pubmed.ncbi.nlm.nih.gov/18405893/
  • https://pubmed.ncbi.nlm.nih.gov/21976775/
  • https://pubmed.ncbi.nlm.nih.gov/25449120/

カスタマーフィードバック

, , Cancer Biol Ther, 2014, 15(12):1646-57.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Disruption of the KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models [ J Clin Invest, 2025, 135(14)e176655] PubMed: 40493396
Long-term real-world PM 2.5 exposure induces depression-like behaviors in mice by disrupting nuclear factor erythroid 2-related factor 2-mediated astrocyte-to-microglia communication [ Neural Regen Res, 2025, 10.4103/NRR.NRR-D-24-01469] PubMed: 40808469
Acupuncture attenuates myocardial ischemia/reperfusion injury-induced ferroptosis via the Nrf2/HO-1 pathway [ Chin Med, 2025, 20(1):61] PubMed: 40346679
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis [ Mil Med Res, 2024, 11(1):22] PubMed: 38622688
Beneficial mechanisms of dimethyl fumarate in autoimmune uveitis: insights from single-cell RNA sequencing [ J Neuroinflammation, 2024, 21(1):112] PubMed: 38684986
Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death [ Cell Death Dis, 2024, 15(3):224] PubMed: 38494482
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects [ Cell Rep Med, 2023, S2666-3791(23)00310-5] PubMed: 37586364
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects [ Cell Rep Med, 2023, 4(9):101157] PubMed: 37586364
Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis [ Cell, 2022, 185(9):1521-1538.e18] PubMed: 35447071
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells [ Mol Cell, 2022, S1097-2765(22)00433-6] PubMed: 35594856

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。