Doxifluridine

製品コードS2045 バッチS204502

印刷

化学情報

Chemical Structure Synonyms 5'-DFUR, AMC 0101 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H11FN2O5
分子量 246.19 CAS No. 3094-09-5
Solubility (25°C)* 体外 DMSO 49 mg/mL (199.03 mM)
Water 49 mg/mL (199.03 mM)
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Doxifluridine (5'-DFUR, AMC 0101) is an oral prodrug that is converted to the cytotoxic agent 5-fluorouracil (5-FU).
in vitro Doxifluridine suppresses tube formation of HUVEC and vascular endothelial growth factor production by FU-MMT-1 cells. [1] This compound is converted to 5-FU and subsequently to FdUMP, and the results suggest that it exerts its cytotoxic effects through inhibition of TS and incorporation into RNA. [2] It is a fluoropyrimidine derivative that is activated preferentially in malignant cells by thymidine phosphorylase to form 5-fluorouracil (5-FU). This chemical is developed to improve the therapeutic index of 5-FU and to reduce toxicity, including the immunosuppressive, myelosuppressive, and cardiotoxic effects of 5-FU and other fluorinated pyrimidines. [3]
in vivo Metronomic Doxifluridine alone significantly suppresses tumor growth compared with the untreated (control) group, while metronomic this compound in combination with TNP-470 significantly inhibits tumor growth compared with each treatment alone in in FU-MMT-1 xenografts. This compound in combination with TNP-470 also leads to a significant reduction of intratumoral vascularity. [1] It significantly inhibits the growth of KPL-4 tumors, reduces the tissue levels of IL-6, and alleviates body weight loss in nude mice bearing KPL-4 tumors. [4] This chemical results in a significant reduction in the activity of phenytoin p-hydroxylation in rats. It decreases the elimination rate constant and the total clearance in rats. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/21631643/
  • https://pubmed.ncbi.nlm.nih.gov/2972339/
  • https://pubmed.ncbi.nlm.nih.gov/23564503/
  • https://pubmed.ncbi.nlm.nih.gov/10500532/
  • https://pubmed.ncbi.nlm.nih.gov/12625878/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Development of an Extracellular Matrix Plate for Drug Screening Using Patient-Derived Tumor Organoids [ BIOCHIP J, 2023, 17, 284–292] PubMed: None
Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin-proteasome pathway [ Acta Histochem, 2022, 124(4):151895] PubMed: 35486967
Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity [Lin KH, et al. Cell Metab, 2019, 29(5):1217-1231] PubMed: 30773463
Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer [Chakrabarti J Oncotarget, 2018, Oncotarget] PubMed: 30647844

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。