受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C14H15N5S |
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分子量 | 285.37 | CAS No. | 152095-12-0 | |
Solubility (25°C)* | 体外 | DMSO | 57 mg/mL warmed with 50ºC water bath (199.74 mM) | |
Ethanol | 47 mg/mL warmed with 50ºC water bath (164.69 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Dp44mT is a potent iron chelator, which shows selective antitumor activity. |
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in vitro | Dp44mT shows pronounced antiproliferative effects in SK-N-MC, SK-Mel-28, and MCF-7 cells with IC50 of 30 nM, 60 nM, and 60 nM, respectively, while no effects on normal MRC-5 fibroblasts. Dp44mT inhibits cellular Fe uptake from Fe-Tf in SK-N-MC neuroepithelioma and M109 cells, and induces cell apoptosis. [1] In MDA-MB-231 cells, Dp44mT specifically targets topoisomerase topo2α, and thus causes DNA damage. [2] Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp). [3] |
in vivo | In CD2F1 mice bearing M109 tumors, Dp44mT (0.4 mg/kg, i.v.) inhibits tumor growth in a dose-dependent manner. [1] |
細胞アッセイ | 細胞株 | SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells |
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濃度 | ~25 μM | |
反応時間 | 72 h | |
実験の流れ | Cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C。 The effect of the chelators on proliferation is examined using the MTT assay. | |
動物実験 | 動物モデル | CD2F1 mice bearing M109 tumors |
投薬量 | 04 mg/kg, twice daily | |
投与方法 | i.v. |
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Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53 [ Evid Based Complement Alternat Med, 2023, 2023:8378581] | PubMed: 36814470 |
Iron Deficiency Increases Phosphorylation of SP1 to Upregulate SPNS2 Expression in Hepatocellular Carcinoma [ Biol Trace Elem Res, 2022, 10.1007/s12011-022-03296-2] | PubMed: 35614326 |
Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma [ Mol Ther, 2021, S1525-0016(21)00467-6] | PubMed: 34547466 |
Impaired-ferritinophagy-flux-induced-by-high-fat-diet-mediates-hepatic-insulin-resistance-via-endoplasmic-reticulum-stress. [ Food-Chem-Toxicol, 2020, 10;140:111329] | PubMed: 32283200 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。