Droperidol

製品コードS4096 バッチS409601

印刷

化学情報

Chemical Structure Synonyms NSC 169874,Dehydrobenzperidol Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C22H22FN3O2
分子量 379.43 CAS No. 548-73-2
Solubility (25°C)* 体外 DMSO 76 mg/mL (200.3 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Droperidol (NSC 169874,Dehydrobenzperidol) is a potent antagonist of dopamine subtype 2 receptors in the limbic system.
in vitro

Droperidol produces mild α-adrenergic blockade and peripheral vascular dilation. Droperidol has been shown to block potassium efflux in the myocardium in isolated animal ventricular myocytes, resulting in a dose-dependent delay in repolarization. Droperidol has also been shown to induce early depolarizations in isolated animal Purkinje fibers. [1]
in vivo

Droperidol (0.01 mM-0.3 mM) increases in a dose-dependent fashion action potential duration (APD) without altering the other parameters in rabbit Purkinje fibers stimulated at 60 pulses/min. Droperidol (1 mM-3 mM) leads to the reversal of the prolonging effect in rabbit Purkinje fibers. Droperidol (10 mM-30 mM) produces shortening in APD at 50% repolarization concomitantly with a significant decrease in Vmax, action potential amplitude and resting membrane potential in rabbit Purkinje fibers. Droperidol exerts a dual effect on repolarization, prolongation with low concentrations with development of EADs and subsequent triggered activity in rabbit Purkinje fibers. [2] Droperidol (3 mg/kg, single dose) decreases dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects of rats. Droperidol (3 mg/kg, long term administration) induces significant tolerance to all parameters of activity recorded in the open-field in rats. Droperidol withdrawn produces an augmented responsiveness to apomorphine-induced stereotyped behavior. [3]

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis [ Front Microbiol, 2022, 13:979904] PubMed: 36386620
Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. [ Sci Rep, 2018, 8(1):15753] PubMed: 30361678

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。