Dydrogesterone

製品コードS4097 バッチS409702

印刷

化学情報

Chemical Structure Synonyms NSC 92336 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C21H28O2
分子量 312.45 CAS No. 152-62-5
Solubility (25°C)* 体外 DMSO 62 mg/mL (198.43 mM)
Ethanol 62 mg/mL (198.43 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
in vitro Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS. [1]
in vivo Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. This compound restores the percentage of CD8+ uterus cells back to levels seen in control mice. It significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. This chemical results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. [2] It abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. This compound increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. It dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice. [3]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/16963030/
  • https://pubmed.ncbi.nlm.nih.gov/15128769/
  • https://pubmed.ncbi.nlm.nih.gov/14667986/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。