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Synonyms | Difluoromethylornithine hydrochloride hydrate, MDL-71782 hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C6H12F2N2O2.HCl.H2O |
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分子量 | 236.64 | CAS No. | 96020-91-6 | |
Solubility (25°C)* | 体外 | Water | 47 mg/mL (198.61 mM) | |
DMSO | ˂1 mg/mL | |||
Ethanol | ˂1 mg/mL | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours. |
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in vitro | When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1]. |
in vivo | Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension |
細胞アッセイ | 細胞株 | BY2 cell |
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濃度 | 2 mM | |
反応時間 | 48 h | |
実験の流れ | BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. |
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動物実験 | 動物モデル | Rats |
投薬量 | 400 mg/kg | |
投与方法 | s.c. |
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WR1065 conjugated to thiol-PEG polymers as novel anticancer prodrugs: broad spectrum efficacy, synergism, and drug resistance reversal [ Front Oncol, 2023, 13:1212604] | PubMed: 37576902 |
Postinfection Metabolic Reprogramming of the Murine Trigeminal Ganglion Limits Herpes Simplex Virus-1 Replication [ mBio, 2022, 13(5):e0219422] | PubMed: 36043789 |
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia [ iScience, 2022, 25(3):103881] | PubMed: 35243242 |
Arginine Regulates Zygotic Genome Activation in Porcine Embryos Under Nutrition Restriction [ Front Vet Sci, 2022, 9:921406] | PubMed: 35812864 |
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity [ Cell, 2021, S0092-8674(21)00700-5] | PubMed: 34216539 |
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19)10255] | PubMed: 34638596 |
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer [ Int J Mol Sci, 2021, 22(19), 10255] | PubMed: None |
Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels. [ Front Cell Infect Microbiol, 2020, 16;10:158] | PubMed: 32373551 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。