Elamipretide (MTP-131, SS-31)

製品コードS9803 バッチS980301

化学情報

	Synonyms	D-Arg-Dmt-Lys-Phe-NH2	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₃₂H₄₉N₉O₅
	分子量	639.79	CAS No.	736992-21-5
Solubility (25°C)*	体外	Water	100 mg/mL (156.3 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
in vitro	SS-31 binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the SS-31/cardiolipin complex inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.^[1]
in vivo	Pretreatment of rats with SS-31 protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.^[1]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	feline kidney cells
	濃度	0.1-10 μM
	反応時間	1 hour
	実験の流れ	Intracellular targeting of SS-31 is determined by incubating feline kidney cells, grown in biotin-free media for 24 hours, with biotinylated SS-31 for 1 hour. Cells are then fixed with 4% paraformaldehyde, permeabilized with 0.1% triton, and treated with Streptavidin-AlexaFluor594 for 30 minutes at room temperature. Fluorescence staining is observed by wide-field fluorescent microscope.
動物実験	動物モデル	male Sprague–Dawley rats
	投薬量	2.0 mg/kg
	投与方法	SC

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Enolase of Streptococcus suis serotype 2 promotes biomolecular condensation of ribosomal protein SA for HBMECs apoptosis [ BMC Biol, 2024, 22(1):33]	PubMed: 38331785
NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation [ bioRxiv, 2024, 2024.02.22.581432]	PubMed: 38464226
Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels [ Geroscience, 2023, 10.1007/s11357-023-00845-y]	PubMed: 37458933
Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS [ Oxid Med Cell Longev, 2022, 2022:4195699]	PubMed: 35847589
High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury - A Potential Mechanism for Obstructive Sleep Apnea with Obesity [ Nat Sci Sleep, 2021, 13:2203-2219]	PubMed: 34992480
Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance [ Sci Adv, 2021, 7(51):eabl4988]	PubMed: 34910515

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。