Eleutheroside B

製品コードS3841 バッチS384101

印刷

化学情報

Chemical Structure Synonyms syringin, Syringoside, Lilacin Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C17H24O9
分子量 372.37 CAS No. 118-34-3
Solubility (25°C)* 体外 DMSO 74 mg/mL (198.72 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Eleutheroside B (syringin, Syringoside, Lilacin) is a phenylpropanoid glycoside first isolated from A. senticosus and has neuroprotective, tonic, adaptogenic, and immune-modulating properties.
in vitro Syringin shows low cytotoxicity on the U937 and PBMC cells with IC50 of >100 and 91.14 mg/mL, respectively[1].
in vivo Syringin has a potent protection against LPS/D-GalN-induced fulminant hepatic failure (FHF), as indicated by the decreased high lethality, alleviates hepatic pathological injury, inhibits hepatocytes apoptosis and reduces hepatic inflammatory responses. Such protective effects are probably carried out through suppression of TNF-α production, which is mediated by NF-kB[2]. Syringin also protects against LPS-induced acute lung injury (ALI) by activating Nrf2 and inhibiting NF-κB signaling pathway[3]. Syringin improves glucose tolerance without increased weight gain in high-fat diet-induced obese mice. It augmentes insulin-stimulated Akt phosphorylation in skeletal muscle, epididymal adipose tissue (EAT), and the liver, showing an insulin-sensitizing activity. Syringin-treated mice also show markedly elevated adiponectin production in EAT and suppresses expression of pro-inflammatory cytokines in peripheral tissues, indicating a significant reduction in low-grade chronic inflammation. Additionally, syringin enhances AMP-activated protein kinase activity and decreases the expression of lipogenic genes in skeletal muscle, which is associated with reduced endoplasmic reticulum (ER) stress[4].

プロトコル(参考用のみ)

動物実験 動物モデル BALB/c mice
投薬量 10, 30 and 100 mg/kg
投与方法 i.p.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。