VX-445 (Elexacaftor)

製品コードS8851 バッチS885101

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂₆H₃₄F₃N₇O₄S
	分子量	597.65	CAS No.	2216712-66-0
Solubility (25°C)*	体外	DMSO	100 mg/mL (167.32 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Elexacaftor (VX-445)は、次世代の嚢胞性線維症膜コンダクタンスレギュレーター（CFTR）コレクターです。これはキラル純度ではない化合物です。
in vitro	The pendrin-dependent increase in cystic fibrosis transmembrane conductance regulator (CFTR) current is additive with the CFTR modulator elexacaftor.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human bronchial epithelial cells from DeltaF508/DeltaF508 Cystic Fibrosis patients (CF HBECs)
	濃度	3 µM
	反応時間	48 h
	実験の流れ	Using Chamber recordings from DeltaF508/DeltaF508 CF HBEC epithelia were treated with the LIE triple combination for 48 h plus and minus 10 ng/mL IL-13 and/or 10 micromol/L niflumic acid (for 30 minutes) again. Transepithelial current (Isc) and conductance (Gt) were measured. (Data sourced from selleck products)

参考

https://pubmed.ncbi.nlm.nih.gov/30334692/
https://pubmed.ncbi.nlm.nih.gov/32923987/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis [ Nucleic Acids Res, 2025, 53(13)gkaf675]	PubMed: 40650978
Antisense oligonucleotide targeting the E3 ligase RFFL potentiates CFTR modulator efficacy in CF primary bronchial epithelial cells [ Mol Ther Nucleic Acids, 2025, 36(4):102756]	PubMed: 41323797
Endometrium-derived organoids from cystic fibrosis patients and mice as new models to study disease-associated endometrial pathobiology [ Cell Mol Life Sci, 2025, 82(1):109]	PubMed: 40074868
CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation [ JCI Insight, 2025, 10(9)e191098]	PubMed: 40131363
Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease [ Stem Cell Res Ther, 2025, 16(1):573]	PubMed: 41116195
In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators [ Br J Pharmacol, 2025, 10.1111/bph.70176]	PubMed: 40831301
Inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma [ Respirology, 2025, 30(1):25-40]	PubMed: 39358991
Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators [ iScience, 2025, 28(3):111942]	PubMed: 40040803
Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide [ iScience, 2025, 28(5):112453]	PubMed: 40395669
Human Induced Lung Organoids: A Promising Tool for Cystic Fibrosis Drug Screening [ Int J Mol Sci, 2025, 26(2)437]	PubMed: 39859153

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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