受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | PF 03491390, PF-03491390 | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C26H27F4N3O7 |
|||
分子量 | 569.50 | CAS No. | 254750-02-2 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (175.59 mM) | |
Ethanol | 100 mg/mL (175.59 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
---|---|
in vitro | Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication[2]. |
in vivo | Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan[1]. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection[2]. |
細胞アッセイ | 細胞株 | Astrocytes |
---|---|---|
濃度 | 9 μM | |
反応時間 | 1 h | |
実験の流れ | Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei. | |
動物実験 | 動物モデル | C57BL/6J mice |
投薬量 | 0.3mg/kg/day | |
投与方法 | i.g. |
|
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia [ Acta Neuropathol, 2024, 147(1):56] | PubMed: 38478117 |
Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis [ Cell Death Differ, 2024, 31(2):254-262.] | PubMed: 38191748 |
Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assays [ bioRxiv, 2024, 2024.03.25.586638] | PubMed: 38586058 |
Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting [ bioRxiv, 2024, 2024.03.11.584478] | PubMed: 38559126 |
Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids [ Cell, 2023, S0092-8674(23)00794-8] | PubMed: 37478861 |
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] | PubMed: 37848438 |
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] | PubMed: 37848438 |
Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis [ Nat Commun, 2023, 14(1):1399] | PubMed: 36918588 |
Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis [ Nat Commun, 2023, 14(1):1399] | PubMed: 36918588 |
Modeling bile duct ischemia and reoxygenation injury in human cholangiocyte organoids for screening of novel cholangio-protective agents [ EBioMedicine, 2023, 88:104431] | PubMed: 36608526 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。