Ensulizole

製品コードS4419 バッチS441901

化学情報

	Synonyms	PBSA	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₃H₁₀N₂O₃S
	分子量	274.30	CAS No.	27503-81-7
Solubility (25°C)*	体外	DMSO	5 mg/mL (18.22 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ensulizole (PBSA), a water soluble sunscreen ingredient, is a sulfonated UV absorber which is characterized by intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.
in vitro	Ensulizole selectively inhibits activity of HDAC3.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	HCT116, HEK293, HepG2, SU-DHL-6 cell lines
	濃度	--
	反応時間	--
	実験の流れ	HCT116, HEK293, HepG2, and SU-DHL-6 cells were seeded into 1536-well white solid bottom assay plates at desired cell densities in 5 μL medium using a microfluidic reagent dispenser. Before plating 5 μL of human neural stem cells into each well, assay plates were pre-coated with 5 μL of 10 μg/mL fibronectin in culture medium at 37°C for one hour and the coating solution was removed by centrifuging the inverted plates. Cells were settled overnight in a cell incubator at 37°C, 5% CO₂, followed by addition of 23 nL of compound solution on a pintool workstation. After compound incubation for indicated period at 37°C/5% CO₂, 5 μL of HDAC-Glo was dispensed using BioRAPTR FRD. To measure cell viability, 5 μL of CellTiter-Glo Cell Viability reagent was added to each well in a separate assay plate using BioRAPTR FRD. The luminescence signals of HDAC-Glo and CellTiter-Glo assays were measured on a ViewLux plate reader. (Data sourced from selleck products)

参考

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。