Etidronate

製品コードS1857 バッチS185701

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂H₈O₇P₂
	分子量	206.03	CAS No.	2809-21-4
Solubility (25°C)*	体外	Water	41 mg/mL (199.0 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Etidronateは非アミノビスホスホネートであり、protein tyrosine phosphatase (PTP)阻害活性を示し、パジェット病の治療および異所性骨化の予防に用いられます。
in vitro	Etidronate inhibits directly osteoclastic bone-resorbing activity by pit assay. This compound also directly induces apoptosis and disrupts actin rings in osteoclasts.
in vivo	Etidronate, when administered s.c. repeatedly at 10 or 40 mg/kg/day, gradually suppresses the adjuvant-induced allodynia In the rats with adjuvant arthritis, as assessed by 10-g von Frey hair. This compound (10-40 mg/kg/day) suppresses the adjuvant-induced mechanical allodynia in rat hindpaw. It (5–10 mg/kg/day) dose-dependently prevents the decrease in bone mineral density (BMD) in the proximal tibia of the arthritic rats. This chemical inhibits the histidine decarboxylase induction, but not the other inflammatory reactions induced by alendronate. It (unlike clodronate) also inhibits alendronate-induced BP-line formation in mice (even at 40 mmol/kg). This compound (160 mmol/kg) also inhibits the physicochemical changes in the tibia induced by six, weekly injections of alendronate. It (10 mg/kg) combined with Calcitriol after subtotal nephrectomy (SNx) significantly inhibits thoracic and abdominal aortic calcification 3 weeks after the operation in rats. This chemical (5 mg/kg or 10 mg/kg) significantly reduces the thoracic and abdominal aortic calcification induced by calcitriol in the renal failure rat. It (5 mg/kg or 10 mg/kg) also reduces the dysfunction in aortic contraction. This compound (5 mg/kg) reverses the reduction in the aortic expression of matrix Gla protein mRNA observed in nephrectomized rats.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/10024379/
https://pubmed.ncbi.nlm.nih.gov/16678221/
https://pubmed.ncbi.nlm.nih.gov/15895282/

https://pubmed.ncbi.nlm.nih.gov/16141638/
https://pubmed.ncbi.nlm.nih.gov/17270170/
https://pubmed.ncbi.nlm.nih.gov/19199933/

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

TRPV1 attenuates epithelial-mesenchymal transition via calpain-protein tyrosine phosphatase pathway in lens epithelial cells [ Exp Eye Res, 2025, 258:110435]	PubMed: 40419208
SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA [ J Immunother Cancer, 2020, 8(2)e001037]	PubMed: 33158915

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。