Etretinate

製品コードS4699 バッチS469901

印刷

化学情報

Synonyms

Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₃H₃₀O₃

分子量

354.48

CAS No.

54350-48-0

Solubility (25°C)*

体外

DMSO

70 mg/mL (197.47 mM)

Ethanol

70 mg/mL (197.47 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) は、乾癬やその他の皮膚症候群に有効な経口芳香族レチノイド酸です。これはレチノイド受容体を活性化し、細胞分化の誘導、細胞増殖の阻害、および炎症性細胞による組織浸潤の阻害を引き起こします。
in vivo	There is a significant decrease in mean dermal thickness (P < 0.05) and changes in collagen bundles in the etretinate-treated mice group for a 28-day period compared to control groups. TUNEL assay shows that the density of TUNEL-positive cells in the dermis of etretinate-treated mice for a 14-day period is significantly increased (P < 0.05). The ratio of procollagen α 1 (I) chain to β actin mRNA from etretinate-treated mice for a 1-day period decreased significantly compared to that of the control mice, but the ratio from etretinatetreated mice for a 14-day period increased significantly (P < 0.05). Etretinate reduces dermal thickness, and suppresses the appearance of skin lesions by inducting apoptosis and perhaps regulation of cytokine expression in MRL/lpr mice.

製品説明

Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) は、乾癬やその他の皮膚症候群に有効な経口芳香族レチノイド酸です。これはレチノイド受容体を活性化し、細胞分化の誘導、細胞増殖の阻害、および炎症性細胞による組織浸潤の阻害を引き起こします。

in vivo

There is a significant decrease in mean dermal thickness (P < 0.05) and changes in collagen bundles in the etretinate-treated mice group for a 28-day period compared to control groups. TUNEL assay shows that the density of TUNEL-positive cells in the dermis of etretinate-treated mice for a 14-day period is significantly increased (P < 0.05). The ratio of procollagen α 1 (I) chain to β actin mRNA from etretinate-treated mice for a 1-day period decreased significantly compared to that of the control mice, but the ratio from etretinatetreated mice for a 14-day period increased significantly (P < 0.05). Etretinate reduces dermal thickness, and suppresses the appearance of skin lesions by inducting apoptosis and perhaps regulation of cytokine expression in MRL/lpr mice.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Human squamous cell carcinoma cell line, HSC-5.
	濃度	5, 10, 25 and 50 nmol⁄L
	反応時間	72 h
	実験の流れ	The HSC-5 cells are plated in 96-well plates at a density of 1.5×10³ per 100 μL and used for experiments. Preliminary experiments are performed to determine the effective dose and cytotoxicity of etretinate. The cells are incubated for 72 h with etretinate at concentrations of 5, 10, 25 and 50 nmol⁄L [dissolved in saline containing 0.0001% dimethyl sulfoxide (DMSO)]. The cells are then incubated for a further 2 h with or without 200 μmol⁄L ALA (Sigma). Each plate is then irradiated using a metal halide lamp at doses of 10, 20, 40 and 80 J⁄cm2
動物実験	動物モデル	BLM-induced sclerotic skin mice
	投薬量	10 mg/kg
	投与方法	oral administration

参考

https://pubmed.ncbi.nlm.nih.gov/19077103/
http://www.sciencedirect.com/science/article/pii/S1323893015310546
https://pubmed.ncbi.nlm.nih.gov/16130505/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3 [ Viruses, 2021, 13(8)1533]	PubMed: 34452398

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3 [ Viruses, 2021, 13(8)1533]

PubMed: 34452398

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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