Eucalyptol

製品コードS3761 バッチS376101

印刷

化学情報

Chemical Structure Synonyms NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole Storage
(From the date of receipt)		 2 years -20°C liquid
化学式

C10H18O
分子量 154.25 CAS No. 470-82-6
Solubility (25°C)* 体外  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

生物活性

製品説明 Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
in vitro

In a concentration-dependent manner, 1,8-Cineol (Eucalyptol) reduces LPS-induced Egr-1 expression in nuclei and in whole cell of THP-1 cells, but shows no effect on NF-κB expression. 1,8-Cineol significantly inhibits cytokine production in human unselected lymphocytes of TNF-α, IL-1β, IL-4, IL-5, and in lipopolysaccharide (LPS)-stimulated monocytes of TNF-α, IL-1β, IL-6, and IL-8[1]. 1,8-Cineol significantly stimulates the transactivation of liver X receptor modulator LXR-α and LXR-β. The mRNA and protein expression of LXRs and their target genes, including ABCA1 and ABCG1, are significantly increased in macrophages stimulated with cineole. This leads to the subsequent removal of cholesterol from the cells[2].
in vivo

In rats, it depresses myocardial contractility in a concentration-dependent way while increasing extracellular Ca2+ concentration. i.v. treatment of both anesthetized and conscious rats with 1,8-cineole lowers blood pressure, probably through an active vascular relaxation rather than withdrawal of sympathetic tone. 1,8-Cineole is also found to relax rat and guinea-pig (nonsensitized and ovalbumin-sensitized) airway smooth muscle by a nonspecific mechanism[2].
密度 0.926 g/mL

プロトコル(参考用のみ)

細胞アッセイ 細胞株 THP-1 cells
濃度 1, 10, and 100 mg/L
反応時間 30 min
実験の流れ

The THP-1 cells are incubated with serial doses of 1,8-cineol (1, 10, and 100 mg/L, 30 min) before being stimulated with LPS (1 mg/L, 30 min). The localization of Egr-1 in the THP-1 cells is detected by immunofluorescence and a laser scanning confocal microscope. The expression of Egr-1 in the nuclei and whole cell, and NF-κB in the nuclei, are measured by Western blot analysis.
動物実験 動物モデル Male Swiss mice, Wistar rats
投薬量 100-400 mg/kg
投与方法 oral

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。