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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C17H16O5 |
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分子量 | 300.31 | CAS No. | 24211-30-1 | |
Solubility (25°C)* | 体外 | DMSO | 60 mg/mL (199.79 mM) | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Farrerol, an important bioactive constituent of rhododendron, exhibits broad activities such as anti-oxidative and anti-inflammatory effects. |
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in vitro | Farrerol observably reduces the production of inflammatory mediators including IL-1β, IL-6, TNF-α, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-κB p65 phosphorylation.[1] |
in vivo | In 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model, Farrerol has a protective effect on TNBS-induced colitis. Farrerol administration significantly improves the weight change, clinical scores, colon length, and intestinal epithelium barrier damage and markedly decreases the production of the inflammatory cytokines in TNBS-induced mice. [1] |
細胞アッセイ | 細胞株 | RAW264.7 cells |
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濃度 | 25 μM-200 μM | |
反応時間 | 1 h | |
実験の流れ | RAW264.7 cells are pretreated with Farrerol for 1 h and then stimulated with LPS (1 μg/mL). RAW264.7 cells or the culture medium are collected and used to measure the reflections of pro-inflammatory mediators and the phosphorylation of signaling pathway by quantitative real-time PCR- and ELISA-analysis, respectively. |
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動物実験 | 動物モデル | 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model (Six- to eight-week-old C57BL/6 mic) |
投薬量 | 45 mg/kg | |
投与方法 | p.o. |
Antioxidant, Anti-Apoptotic, and Anti-Inflammatory Effects of Farrerol in a Mouse Model of Obstructive Uropathy [ Curr Issues Mol Biol, 2023, 45(1):337-352] | PubMed: 36661510 |
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro [ Front Pharmacol, 2022, 13:1079251] | PubMed: 36686707 |
Farrerol exhibits inhibitory effects on lung adenocarcinoma cells by activating the mitochondrial apoptotic pathway [ J Biochem Mol Toxicol, 2022, 36(10):e23157] | PubMed: 35833306 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。