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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C₁₆H₁₅F₂N |
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分子量 | 259.29 | CAS No. | 1266684-01-8 | |
Solubility (25°C)* | 体外 | DMSO | 52 mg/mL (200.54 mM) | |
Ethanol | 13 mg/mL (50.13 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A. |
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in vitro | FIDAS-3 inhibits Methionine S-adenosyltransferase 2A (MAT2A) activity in S-adenosylmethionine (SAM) synthesis, leading to the inhibition of CRC cell growth.[1] |
in vivo | FIDAS-3 represses the growth of human CRC xenografts in athymic nude mice with no notable effects on body weight.FIDAS-3 represses the growth of human CRC xenografts in athymic nude mice with no notable effects on body weight. [1] |
細胞アッセイ | 細胞株 | LS174T cells |
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濃度 | 3-10 μM | |
反応時間 | 36 h | |
実験の流れ | For cell based assay(Western blotting ; Cell proliferatio; shRNA assay), LS174T cells are cultured in RPMI1640 medium containing 5% FBS. Cells are treated with FIDAS agents for 36 h and then harvested and weighed. Perchloric acid (0.4 M) is added to cell pellet (100 μL/30mg) for deproteinization. |
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動物実験 | 動物モデル | Athymic nude mice bearing with HT29 CRC cells |
投薬量 | 20 mg/kg | |
投与方法 | o.g. |
Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment [ Cell Death Dis, 2023, 14(8):525] | PubMed: 37582769 |
Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment [ Cell Death Dis, 2023, 14(8):525] | PubMed: 37582769 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。