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Synonyms | FTY-720A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C19H33NO2 |
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分子量 | 307.47 | CAS No. | 162359-55-9 | |
Solubility (25°C)* | 体外 | DMSO | 13 mg/mL (42.28 mM) | |
Ethanol | 5 mg/mL (16.26 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Fingolimod (FTY-720) is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. |
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in vitro | The main immunomodulatory mechanism of action of fingolimod is based on its effect on lymphocyte homing. It reversibly redistributes T and B cells from the circulation to secondary lymphoid organs like peripheral and mesenteric lymph nodes and Peyer's patches, thereby causing a state of peripheral lymphopenia[1]. |
in vivo | SphK2 is the only enzyme which activates fingolimod in vivo,since only Sphk2 knockout mice are resistant to fingolimod-induced lymphopenia. A major advantage of fingolimod as a therapeutic agent is the possibility of its oral application. Absorption is food-independent and slow (maximal plasma concentration after 12-16 h), but extensive, and its bioavailability is high (93%). It reaches steady state concentrations after 1-2 months during daily intake. Fingolimod shows high plasma protein binding (>99.7%), mainly to albumin, and in contrast to S1P, there is no evidence for fingolimod binding to ApoM/HDL. It has a large volume of distribution of approx. 20L/kg and shows slow blood clearance (6.3±2.3 L/h), resulting in a half-life of 6-9 days[1]. Fingolimod alleviates disease burden in immune-mediated animal models of multiple sclerosis[2]. |
細胞アッセイ | 細胞株 | NSCLC cells |
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濃度 | 10 μM | |
反応時間 | 72 h | |
実験の流れ | Cells were treated with various concentrations of drug for 72 h. |
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動物実験 | 動物モデル | C57/B6 mice |
投薬量 | 1 mg/kg | |
投与方法 | o.g. |
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A novel isoxazole compound CM2-II-173 inhibits the invasive phenotype of triple-negative breast cancer cells [ Oncol Res, 2023, 31(6):867-875] | PubMed: 37744269 |
Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity [ J Clin Invest, 2022, 132(3)e153604] | PubMed: 35104810 |
Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity [ J Clin Invest, 2022, 132(3)e153604] | PubMed: 35104810 |
Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy [ J Immunother Cancer, 2022, 10(5)e003960] | PubMed: 35623658 |
The central role of Sphingosine kinase 1 in the development of neuroendocrine prostate cancer (NEPC): A new targeted therapy of NEPC [ Clin Transl Med, 2022, 12(2):e695] | PubMed: 35184376 |
The sphingosine kinase inhibitor SKI-V suppresses cervical cancer cell growth [ Int J Biol Sci, 2022, 18(7):2994-3005] | PubMed: 35541904 |
Targeting sphingosine kinase 1/2 by a novel dual inhibitor SKI-349 suppresses non-small cell lung cancer cell growth [ Cell Death Dis, 2022, 13(7):602] | PubMed: 35831279 |
Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis [ Pharmaceutics, 2022, 14(7)1420] | PubMed: 35890315 |
The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function [ Cell, 2021, 184(19):4981-4995.e14] | PubMed: 34464586 |
ChenThe interplay between fibroblast-like synovial and vascular endothelial cells leads to angiogenesis via the sphingosine-1-phosphate-induced RhoA-F-Actin and Ras-Erk1/2 pathways and the intervention of geniposide [ Phytother Res, 2021, 10.1002/ptr.7211] | PubMed: 34327764 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。