Flavone

製品コードS3967 バッチS396701

印刷

化学情報

Chemical Structure Synonyms 2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C15H10O2
分子量 222.24 CAS No. 525-82-6
Solubility (25°C)* 体外 DMSO 44 mg/mL (197.98 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
in vitro Flavone is found to reduce cell proliferation in HT-29 cells with an EC50 value of 54.8 ± 1.3 μm and to potently induce differentiation as well as apoptosis. The effects of flavone in HT-29 cells are associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor κB (NF-κB), and bcl-XL. Moreover, flavone displays a high selectivity for the induction of apoptosis and of growth inhibition only in the transformed colonocytes[1].
in vivo In vivo anti-tumor study indicates that flavone exhibits ability to inhibit tumor formation elicited by s.c. injection of COLO205 cells in nude mice. Apoptotic cells and an increase in p21, but not p53, protein are observed in tumor tissues derived from flavone-treated group. Flavone has been shown to accumulate in intestinal cells suggesting the potential application of flavone in treatment of colorectal carcinoma[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 HT-29 Cells
濃度 1-1000 μM
反応時間 72 h
実験の流れ

Cells (5 × 103 per well) are incubated for 72 h with medium alone (control) or containing the compounds at various concentrations and cell numbers are determined subsequently using SYTOX-Green nucleic acid stain.
動物実験 動物モデル Male BALB/c nu/nu mice (Tumor-bearing mice injected COLO205 cells s.c.)
投薬量 10 and 20 mg/kg
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

RORγ Is a Targetable Master Regulator of Cholesterol Biosynthesis in a Cancer Subtype [ Nat Commun, 2019, 11;10(1):4621] PubMed: 31604910

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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