Flumethasone

製品コードS4088 バッチS408801

化学情報

	Synonyms	RS-2177, NSC-54702,Flumetasone	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₂H₂₈F₂O₅
	分子量	410.45	CAS No.	2135-17-3
Solubility (25°C)*	体外	DMSO	82 mg/mL (199.78 mM)
		Ethanol	6 mg/mL (14.61 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.
in vivo	Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. ^[1] Flumethasone combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. ^[2] Flumethasone (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. Flumethasone (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. ^[3] The Flumethasone level in the treated animals is generally above the detection limit although, in most cases, the concentration of Flumethasone is lower than the corresponding glucocorticoid level in the dexamethasone-exposed calves. Flumethasone is also detectable in the accompanying urine samples in calves. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. ^[4]

製品説明

Flumethasone (RS-2177, NSC-54702,Flumetasone) is a glucocorticoid receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.

in vivo

Flumethasone (0.5 mg/100 kg b.w.) reduces insulin-dependent glucose utilization in calves at 24 hours after treatment. ^[1] Flumethasone combined with sodium ceftiofur reduces the mortality rate in calves with severe acute bronchopneumonia and their clinical and haematological parameters returns to normal significantly faster than in the control calves. ^[2] Flumethasone (5 mg) has a significant effect on recovery of uterine disease in cattle with ketosis. Flumethasone (5 mg) increases plasma glucose concentration and decreases serum beta-hydroxybutyric acid and urine acetoacetate concentrations following treatment in cattle with ketosis. ^[3] The Flumethasone level in the treated animals is generally above the detection limit although, in most cases, the concentration of Flumethasone is lower than the corresponding glucocorticoid level in the dexamethasone-exposed calves. Flumethasone is also detectable in the accompanying urine samples in calves. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. ^[4]

プロトコル(参考用のみ)

参考

[4] Van Den Hauwe O, et al. J Agric Food Chem, 2003, 51(1), 326-330.

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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