Furosemide sodium

製品コードS5194 バッチS519401

印刷

化学情報

Chemical Structure Synonyms Lasix, Frusemide Sodium Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C12H10ClN2NaO5S
分子量 352.73 CAS No. 41733-55-5
Solubility (25°C)* 体外 DMSO 71 mg/mL (201.28 mM)
Water 71 mg/mL (201.28 mM)
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明 Furosemide (Frusemide) sodiumは、強力で経口活性のあるNa-K-Cl共輸送体 (NKCC)の阻害剤です。Furosemide sodiumは、γ-アミノ酪酸A型 (GABAA) 受容体のサブタイプ選択的拮抗薬です。
in vitro

Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF.  Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells.  Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model.  Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. 
in vivo

Furosemide (0.25 to 2 mg/kg), administered 4 hours before exercise, reduces right atrial pressure (RAP) and pulmonary arterial pressure (PAP) during exercise in dose-dependent manner in horse. 

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/2050599/
  • https://pubmed.ncbi.nlm.nih.gov/7996475/
  • https://pubmed.ncbi.nlm.nih.gov/10391452/
  • https://pubmed.ncbi.nlm.nih.gov/17052386/
  • https://pubmed.ncbi.nlm.nih.gov/1524299/
  • https://pubmed.ncbi.nlm.nih.gov/8663127/
  • https://pubmed.ncbi.nlm.nih.gov/9138676/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory [ Nat Commun, 2024, 15(1):7342] PubMed: 39187496
A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium [ Ren Fail, 2022, 44(1):1345-1355] PubMed: 35938700

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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