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Synonyms | ARRY-575, RG7741 | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C16H20BrN5O |
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分子量 | 378.27 | CAS No. | 1196541-47-5 | |
Solubility (25°C)* | 体外 | DMSO | 75 mg/mL (198.27 mM) | |
Ethanol | 5 mg/mL (13.21 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | GDC-0575 is a potent and selective CHK1 inhibitor with an IC50 of 1.2 nM. |
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in vitro | GDC-0575 enhances the cytotoxicity of Cytarabine (AraC) in vitro[1]. |
in vivo | GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor that results in tumor shrinkage and growth delay in xenograft models[2]. |
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Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition [ Front Cardiovasc Med, 2023, 10:1187490] | PubMed: 37711550 |
Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition [ Front Cardiovasc Med, 2023, 10:1187490] | PubMed: 37711550 |
Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells [ J Exp Clin Cancer Res, 2022, 41(1):141] | PubMed: 35418303 |
A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer [ Biochem Biophys Res Commun, 2021, 584:7-14] | PubMed: 34753066 |
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma [ J Clin Invest, 2020, 139080] | PubMed: 33016928 |
Small Molecule Inhibitors and a Kinase-Dead Expressing Mouse Model Demonstrate That the Kinase Activity of Chk1 Is Essential for Mouse Embryos and Cancer Cells [ Life Sci Alliance, 2020, 3(8):e202000671] | PubMed: 32571801 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。