Gibberellic acid

製品コードS4766 バッチS476601

化学情報

	Synonyms	Gibberellin, Gibberellin A3, GA3	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₉H₂₂O₆
	分子量	346.37	CAS No.	77-06-5
Solubility (25°C)*	体外	DMSO	69 mg/mL (199.2 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.
in vivo	Gibberellic acid (GA3) acts as an agonist of steroidogenesis in male rats. Administration of GA3 to rat causes reduction in liver carbohydrates, total protein content, serum levels of aspartate and alanine amino transferases and alkaline phosphatase in a time- and dose- dependent mannner. It is reported that GA3 causes hepatonephrotoxicity, oxidative stress and DNA damage in rat testis. Abscisic acid and GA3 have been found to affect sexual differentiation and other physiological characteristics in mice^[1]. Gibberellic acid is tested by various routes in mice for its acute toxicity and found to be essentially nontoxic. Both subacute toxicity in mice and subchronic toxicity in dogs and rats show the compound to be asymptomatic and free of pathologic changes, histologically. The highest observed nontoxic (and asymptomatic) doses in mice as determined by acute toxicity testing are as follows: 4 Gm./Kg., intravenously; 15 Gm./Kg., orally; and 2 Gm./Kg., intraperitoneally^[2].

製品説明

Gibberellic acid (Gibberellin, Gibberellin A3, GA3, GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound.

in vivo

Gibberellic acid (GA3) acts as an agonist of steroidogenesis in male rats. Administration of GA3 to rat causes reduction in liver carbohydrates, total protein content, serum levels of aspartate and alanine amino transferases and alkaline phosphatase in a time- and dose- dependent mannner. It is reported that GA3 causes hepatonephrotoxicity, oxidative stress and DNA damage in rat testis. Abscisic acid and GA3 have been found to affect sexual differentiation and other physiological characteristics in mice^[1]. Gibberellic acid is tested by various routes in mice for its acute toxicity and found to be essentially nontoxic. Both subacute toxicity in mice and subchronic toxicity in dogs and rats show the compound to be asymptomatic and free of pathologic changes, histologically. The highest observed nontoxic (and asymptomatic) doses in mice as determined by acute toxicity testing are as follows: 4 Gm./Kg., intravenously; 15 Gm./Kg., orally; and 2 Gm./Kg., intraperitoneally^[2].

プロトコル(参考用のみ)

動物実験	動物モデル	normal and diabetic Wistar male rats
	投薬量	150 μg/day
	投与方法	Oral administration

参考

[1] Premalatha R, et al. Andrologia. 2014, 46(8):902-9.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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