Ginsenoside Rd

製品コードS3931 バッチS393102

印刷

化学情報

Chemical Structure Synonyms Panaxoside Rd, Sanchinoside Rd Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C48H82O18
分子量 947.15 CAS No. 52705-93-8
Solubility (25°C)* 体外 DMSO 90 mg/mL (95.02 mM)
Ethanol 90 mg/mL (95.02 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
in vitro

Ginsenoside Rd is a selective and competitive Ca2+ receptor antagonist and herefore, can suppress calcium influx after cytotoxic injuries. Ginsenoside Rd administration dose-dependently suppresses glutamate-induced DNA laddering and apoptosis through the suppression of glutamate-induced caspase-3 activation and Ca2+ entry. Exposure to ginsenoside Rd can also protect mitochondria against calcium-induced damages through downregulation of reactive oxygen species generation, suppression of mitochondrial membrane potential hyperpolarization, and amelioration of mitochondrial swelling[1]. Ginsenoside Rd is a potent in vitro inhibitor on the chymotrypsin-like activity of 26S proteasome[2].
in vivo

Ginsenoside Rd treatment prior to and/or following an ischemic stroke can reduce infarct volume, increase neuronal survival, and enhance cognitive and neurological functions. Ginsenoside Rd administration to a Sprague-Dawley rat has been shown to downregulate ischemic stroke-induced tau protein phosphorylation at Ser199/202 and PHF-1 sites through the downregulation of glycogen synthase kinase-3β and to enhance ischemia-induced cognitive impairment. Ginsenoside Rd administration has also been shown to upregulate the protein kinase B/AKT pathway and, from this, suppress glycogen synthase kinase-3β activity. Ginsenoside Rd administration after tMCAO upregulates glial glutamate transporter-1 (GLT-1) expression and promotes glutamate clearance in rats. Pretreatment with ginsenoside Rd (10 mg/kg) inhibits poly(ADP-ribose) polymerase-1 and consequently downregulates apoptosis-inducing factor translocation and nuclear factor-kappa B p65 subunit nuclear accumulation in Dawley rats suffering from right middle cerebral artery occlusion[1].

プロトコル(参考用のみ)

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ginsenoside Rd Promotes Cardiac Repair After Myocardial Infarction by Modulating Monocytes/Macrophages Subsets Conversion [ Drug Des Devel Ther, 2022, 16:2767-2782] PubMed: 36033133
Ginsenoside Rd protects cerebral endothelial cells from oxygen-glucose deprivation/reoxygenation induced pyroptosis via inhibiting SLC5A1 mediated sodium influx [ J Ginseng Res, 2022, 46(5):700-709] PubMed: 36090684
Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo [ J Ethnopharmacol, 2021, S0378-8741(21)00169-0] PubMed: 33617967

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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